Efficacy of Topical Application of a Skin Moisturizer Containing Pseudo-Ceramide and a Eucalyptus Leaf Extract on Atopic Dermatitis: A Review

被引：1
|
作者：
Takagi, Yutaka [1 ]
机构：
[1] Josai Univ, Fac Pharmaceut Sci, Saitama 3500295, Japan
来源：
JOURNAL OF CLINICAL MEDICINE | 2024年 / 13卷 / 06期
关键词：
ceramides; barrier function; water holding capacity; sweating; eucalyptus leaf extract (ELE); pseudo-ceramide; SLE66; FILAGGRIN NULL MUTATIONS; STRATUM-CORNEUM LIPIDS; OF-FUNCTION MUTATIONS; HMG-COA REDUCTASE; BARRIER FUNCTION; ANTIMICROBIAL PEPTIDES; ICHTHYOSIS VULGARIS; COMPREHENSIVE QUANTIFICATION; JAPANESE-POPULATION; PREDISPOSING FACTOR;
D O I：
10.3390/jcm13061749
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Atopic dermatitis (AD) is a chronic inflammatory skin disease associated with pruritus, an impaired cutaneous barrier function and a disrupted water holding capacity. Levels of ceramides, which are major components of intercellular lipids and are crucial for their functions, are decreased in the stratum corneum of patients with AD. Treatments to increase ceramide levels are effective for AD care. Synthetic pseudo-ceramide (cetyl PG hydroxyethyl palmitamide (SLE66)), which has a structure developed via molecular designs, and a eucalyptus leaf extract (ELE) enhance ceramide synthesis in the epidermis. The topical application of a skin moisturizer containing SLE66 and ELE improves the barrier functions and water holding capacity of AD skin accompanied by an improvement in skin symptoms. This is a multifaceted review that summarizes the efficacy of the topical application of a skin moisturizer containing SLE66 and ELE on atopic dermatitis.
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页数：15
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