Nanotechnology-based Drug Delivery for Alzheimer's and Parkinson's Diseases

被引：1

作者：

Nguyen-Thi, Phuong-Trang ^{[1
]}

Ho, Thanh-Tam ^{[2
,3
]}

Nguyen, Thuy Trang ^{[4
]}

Van Vo, Giau ^{[5
,6
,7
]}

机构：

[1] HUTECH Univ, Fac Pharm, Ho Chi Minh 700000, Vietnam

[2] Duy Tan Univ, Inst Global Hlth Innovat, Da Nang 550000, Vietnam

[3] Duy Tan Univ, Fac Pharm, Da Nang 550000, Vietnam

[4] Ind Univ Ho Chi Minh City, Fac Chem Engn, Ho Chi Minh, Vietnam

[5] Vietnam Natl Univ Ho Chi Minh City VNU HCM, Sch Med, Dept Biomed Engn, Ho Chi Minh City, Vietnam

[6] Vietnam Natl Univ, Res Ctr Genet & Reprod Hlth CGRH, Sch Med, Ho Chi Minh City VNU HCM, Ho Chi Minh 70000, Vietnam

[7] Vietnam Natl Univ, Ho Chi Minh City VNU HCM, Ho Chi Minh 700000, Vietnam

来源：

CURRENT DRUG DELIVERY | 2024年 / 21卷 / 07期

关键词：

CNS; Nanoparticles; Molecular targets; Oxidative stress; Nanomedicine; PD/AD; BLOOD-BRAIN-BARRIER; LOADED CHITOSAN NANOPARTICLES; LIPID NANOPARTICLES; RAT MODEL; GOLD NANOPARTICLES; MOUSE MODEL; TRANSPORT; NOSE; NEUROPROTECTION; RIVASTIGMINE;

D O I：

10.2174/1567201820666230707113405

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The delivery of drugs to the brain is quite challenging in the treatment of the central nervous system (CNS) diseases due to the blood-brain barrier and the blood-cerebrospinal fluid barrier. However, significant developments in nanomaterials employed by nanoparticle drug-delivery systems have substantial potential to cross or bypass these barriers leading to enhanced therapeutic efficacies. Advances in nanoplatform, nanosystems based on lipids, polymers and inorganic materials have been extensively studied and applied in treating Alzheimer's and Parkinson's diseases. In this review, various types of brain drug delivery nanocarriers are classified, summarized, and their potential as drug delivery systems in Alzheimer's and Parkinson's diseases is discussed. Finally, challenges facing the clinical translation of nanoparticles from bench to bedside are highlighted.

引用

页码：917 / 931

页数：15

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