Continuous stirred tank reactors in fine chemical synthesis for efficient mixing, solids-handling, and rapid scale-up

被引：28
|
作者：
Cherkasov, Nikolay [1 ,2 ]
Adams, Samuel J. [1 ]
Bainbridge, Edward G. A. [1 ]
Thornton, Jonty A. M. [1 ]
机构：
[1] Stoli Chem, Prince Phillip Bldg, Wellesbourne CV35 9EF, England
[2] Univ Warwick, Sch Engn, Coventry CV4 7AL, England
来源：
REACTION CHEMISTRY & ENGINEERING | 2023年 / 8卷 / 02期
关键词：
CONTINUOUS REACTIVE CRYSTALLIZATION; CASCADE; DESIGN; BATCH;
D O I：
10.1039/d2re00232a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Continuous stirred tank reactors (CSTRs) facilitate chemical manufacture in continuous flow and have been used for decades. They excel at solid handling and have well understood scale-up capacity. CSTRs in series (CSTR cascades) improve residence time distribution control by exhibiting pseudo plug flow characteristics. Advanced CSTR systems incorporate multiple vessels into a single reactor to simplify design and improve reliability. This review discusses the benefits and limitations of single CSTR technology and CSTR cascades in pharmaceutical and fine chemical synthesis compared with batch, coil (tubular) and plate reactors. In addition, we cover the measurement and importance of residence time distribution in chemical and crystallisation processes. CSTRs demonstrate substantial benefits compared with batch of up to 31% yield increase, 70% cost, and 80% energy reduction. In addition, such continuous manufacturing reduces operational complexity, reliability, and plant footprint.
引用
收藏
页码：266 / 277
页数：12
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  • [1] SCALE-UP OF CONTINUOUS FLOW STIRRED TANK REACTORS
    KEAIRNS, DL
    CANADIAN JOURNAL OF CHEMICAL ENGINEERING, 1969, 47 (04): : 395 - &
  • [2] SCALE-UP CRITERIA FOR STIRRED TANK REACTORS
    EVANGELISTA, JJ
    KATZ, S
    SHINNAR, R
    AICHE JOURNAL, 1969, 15 (06) : 843 - +
  • [3] Study on mixing in scale-up of stirred tank reactor for continuous bulk polymerization
    Fuchigami, Y
    Nagai, M
    Sugiyama, T
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  • [10] RELATIONSHIPS BETWEEN SOLIDS SUSPENSION CRITERIA, MECHANISM OF SUSPENSION, TANK GEOMETRY, AND SCALE-UP PARAMETERS IN STIRRED TANKS
    CHUDACEK, MW
    INDUSTRIAL & ENGINEERING CHEMISTRY FUNDAMENTALS, 1986, 25 (03): : 391 - 401
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