Recent Developments in the Biological Activities, Bioproduction, and Applications of Pseudomonas spp. Phenazines

被引：23
|
作者：
Serafim, Bruno [1 ,2 ]
Bernardino, Ana R. [1 ,2 ]
Freitas, Filomena [1 ,2 ]
Torres, Cristiana A. V. [1 ,2 ]
机构：
[1] NOVA Univ Lisbon, Inst Hlth & Bioecon, Sch Sci & Technol, Lab i4HB, P-2825149 Caparica, Portugal
[2] NOVA Univ Lisbon, Sch Sci & Technol, Dept Chem, Appl Mol Biosci Unit,UCIBIO, P-2825149 Caparica, Portugal
来源：
MOLECULES | 2023年 / 28卷 / 03期
关键词：
phenazines; Pseudomonas spp; bioprocess; PHENAZINE-1-CARBOXYLIC ACID PRODUCTION; PHENAZINE-1,6-DICARBOXYLIC ACID; FLUORESCENT PSEUDOMONAS; BIOACTIVE METABOLITES; CHLORORAPHIS GP72; REGULATORY ROLES; CARBOXYLIC-ACID; SHEATH BLIGHT; PROTEIN PHZF; BIOSYNTHESIS;
D O I：
10.3390/molecules28031368
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Phenazines are a large group of heterocyclic nitrogen-containing compounds with demonstrated insecticidal, antimicrobial, antiparasitic, and anticancer activities. These natural compounds are synthesized by several microorganisms originating from diverse habitats, including marine and terrestrial sources. The most well-studied producers belong to the Pseudomonas genus, which has been extensively investigated over the years for its ability to synthesize phenazines. This review is focused on the research performed on pseudomonads' phenazines in recent years. Their biosynthetic pathways, mechanism of regulation, production processes, bioactivities, and applications are revised in this manuscript.
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页数：18
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