The interplay of signaling pathways and miRNAs in the pathogenesis and targeted therapy of esophageal cancer

被引：39
|
作者：
Doghish, Ahmed S. [1 ,2 ]
El-Husseiny, Ahmed A. [2 ,3 ]
Abdelmaksoud, Nourhan M. [4 ]
El-Mahdy, Hesham A. [2 ]
Elsakka, Elsayed G. E. [2 ]
Mageed, Sherif S. Abdel [5 ]
Mahmoud, Abdulla M. A. [5 ]
Raouf, Ahmed Amr [5 ]
Elballal, Mohammed S. [1 ]
El-Dakroury, Walaa A. [6 ]
AbdelRazek, Mohamed M. M. [7 ]
Noshy, Mina [8 ]
El-Husseiny, Hussein M. [9 ,10 ]
Abulsoud, Ahmed I. [2 ,4 ]
机构：
[1] Badr Univ Cairo BUC, Fac Pharm, Dept Biochem, Cairo 11829, Egypt
[2] Al Azhar Univ, Fac Pharm Boys, Biochem & Mol Biol Dept, Cairo 11231, Egypt
[3] Egyptian Russian Univ, Fac Pharm, Dept Biochem, Cairo 11829, Egypt
[4] Heliopolis Univ, Fac Pharm, Dept Biochem & Biotechnol, Cairo 11785, Egypt
[5] Badr Univ Cairo BUC, Fac Pharm, Pharmacol & Toxicol Dept, Cairo 11829, Egypt
[6] Badr Univ Cairo BUC, Fac Pharm, Dept Pharmaceut & Ind Pharm, Cairo 11829, Egypt
[7] Badr Univ Cairo BUC, Fac Pharm, Dept Pharmacognosy, Cairo 11829, Egypt
[8] King Salman Int Univ KSIU, Fac Pharm, Clin Pharm Dept, Ras Sudr 46612, Egypt
[9] Tokyo Univ Agr & Technol, Fac Agr, Cooperat Dept Vet Med, 3-5-8 Saiwai Cho, Fuchu, Tokyo 1838509, Japan
[10] Benha Univ, Fac Vet Med, Dept Surg Anesthesiol & Radiol, Toukh 13736, Elqaliobiya, Egypt
来源：
PATHOLOGY RESEARCH AND PRACTICE | 2023年 / 246卷
关键词：
Esophageal cancer; Tumor suppressor miRNA; Oncogenic miRNA; Epithelial-mesenchymal transition; Chemoresistance; SQUAMOUS-CELL CARCINOMA; EPITHELIAL-MESENCHYMAL TRANSITION; POTENTIAL VEGFR-2 INHIBITORS; CISPLATIN-INDUCED APOPTOSIS; PROMOTES MIGRATION; HEPATOCELLULAR-CARCINOMA; MICRORNA-21; PROMOTES; PROGNOSTIC BIOMARKER; BARRETTS-ESOPHAGUS; MIR-21; EXPRESSION;
D O I：
10.1016/j.prp.2023.154529
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Globally, esophageal cancer (EC) is the 6th leading cause of cancer-related deaths and the second deadliest gastrointestinal cancer. Multiple genetic and epigenetic factors, such as microRNAs (miRNAs), influence its onset and progression. miRNAs are short nucleic acid molecules that can regulate multiple cellular processes by regulating gene expression. Therefore, EC initiation, progression, apoptosis evasions, invasion capacity, promotion, angiogenesis, and epithelial-mesenchymal transition (EMT) enhancement are associated with miRNA expression dysregulation. Wnt/-catenin signaling, Mammalian target of rapamycin (mTOR)/P-gp, phosphoinositide-3-kinase (PI3K)/AKT/c-Myc, epidermal growth factor receptor (EGFR), and transforming growth factor (TGF)-& beta; signaling are crucial pathways in EC that are controlled by miRNAs. This review was conducted to provide an up-to-date assessment of the role of microRNAs in EC pathogenesis and their modulatory effects on responses to various EC treatment modalities.
引用
收藏
页数：17
相关论文
共 50 条
  • [1] miRNAs role in cervical cancer pathogenesis and targeted therapy: Signaling pathways interplay
    Doghish, Ahmed S.
    Ali, Mohamed A.
    Elyan, Salah S.
    Elrebehy, Mahmoud A.
    Mohamed, Hend H.
    Mansour, Reda M.
    Elgohary, Ayatallah
    Ghanem, Aml
    Faraag, Ahmed H. I.
    Abdelmaksoud, Nourhan M.
    Moustafa, Hebatallah Ahmed Mohamed
    [J]. PATHOLOGY RESEARCH AND PRACTICE, 2023, 244
  • [2] miRNAs role in glioblastoma pathogenesis and targeted therapy: Signaling pathways interplay
    Elshaer, Shereen Saeid
    Abulsoud, Ahmed I.
    Fathi, Doaa
    Abdelmaksoud, Nourhan M.
    Zaki, Mohamed Bakr
    El-Mahdy, Hesham A.
    Ismail, Ahmed
    Elsakka, Elsayed G. E.
    Abd-Elmawla, Mai A.
    Abulsoud, Logyna A.
    Doghish, Ahmed S.
    [J]. PATHOLOGY RESEARCH AND PRACTICE, 2023, 246
  • [3] miRNAs role in bladder cancer pathogenesis and targeted therapy: Signaling pathways interplay-A review
    El-Mahdy, Hesham A.
    Elsakka, Elsayed G. E.
    El-Husseiny, Ahmed A.
    Ismail, Ahmed
    Yehia, Amr Mohamed
    Abdelmaksoud, Nourhan M.
    Elshimy, Reham A. A.
    Noshy, Mina
    Doghish, Ahmed S.
    [J]. PATHOLOGY RESEARCH AND PRACTICE, 2023, 242
  • [4] The interplay of signaling pathways with miRNAs in cholangiocarcinoma pathogenicity and targeted therapy
    Zaki, Mohamed Bakr
    Abulsoud, Ahmed I.
    Elshaer, Shereen Saeid
    Fathi, Doaa
    Abdelmaksoud, Nourhan M.
    El-Mahdy, Hesham A.
    Ismail, Ahmed
    Elsakka, Elsayed G. E.
    Sallam, Al-Aliaa M.
    Doghish, Ahmed S.
    [J]. PATHOLOGY RESEARCH AND PRACTICE, 2023, 245
  • [5] miRNAs as cornerstones in colorectal cancer pathogenesis and resistance to therapy: A spotlight on signaling pathways interplay-A review
    Elrebehy, Mahmoud A.
    Al-Saeed, Sarah
    Gamal, Sara
    El-Sayed, Asmaa
    Ahmed, Alshaimaa A.
    Waheed, Omnia
    Ismail, Ahmed
    El-Mahdy, Hesham A.
    Sallam, Al-Aliaa M.
    Doghish, Ahmed S.
    [J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2022, 214 : 583 - 600
  • [6] The potential role of miRNAs in the pathogenesis of gallbladder cancer - A focus on signaling pathways interplay
    Doghish, Ahmed S.
    Midan, Heba M.
    Elbadry, Abdullah M. M.
    Darwish, Samar F.
    Rizk, Nehal I.
    Ziada, Bassant O.
    Elbokhomy, Amir S.
    Elrebehy, Mahmoud A.
    Elballal, Mohammed S.
    El-Husseiny, Hussein M.
    Mageed, Sherif S. Abdel
    Abulsoud, Ahmed I.
    [J]. PATHOLOGY RESEARCH AND PRACTICE, 2023, 248
  • [7] Signaling pathways in liver cancer: pathogenesis and targeted therapy
    Xue, Yangtao
    Ruan, Yeling
    Wang, Yali
    Xiao, Peng
    Xu, Junjie
    [J]. MOLECULAR BIOMEDICINE, 2024, 5 (01):
  • [8] miRNAs Role in Wilms tumor pathogenesis: Signaling pathways interplay
    Alfaifi, Jaber
    [J]. PATHOLOGY RESEARCH AND PRACTICE, 2024, 256
  • [9] The potential role of miRNAs in the pathogenesis of salivary gland cancer - A Focus on signaling pathways interplay
    Abulsoud, Ahmed I.
    Elshaer, Shereen Saeid
    El-Husseiny, Ahmed A.
    Fathi, Doaa
    Abdelmaksoud, Nourhan M.
    Mageed, Sherif S. Abdel
    Salman, Aya
    Zaki, Mohamed Bakr
    El-Mahdy, Hesham A.
    Ismail, Ahmed
    Elsakka, Elsayed G. E.
    Abd-Elmawla, Mai A.
    El-Husseiny, Hussein M.
    Ibrahim, Wael S.
    Doghish, Ahmed S.
    [J]. PATHOLOGY RESEARCH AND PRACTICE, 2023, 247
  • [10] The potential role of miRNAs in the pathogenesis of schizophrenia - A focus on signaling pathways interplay
    Zaki, Mohamed Bakr
    Abulsoud, Ahmed I.
    Ashraf, Alaa
    Abdelmaksoud, Nourhan M.
    Sallam, Al-Aliaa M.
    Aly, Shaza H.
    El-Tokhy, Fatma Sa'eed
    Rashad, Ahmed A.
    El-Dakroury, Walaa A.
    Mageed, Sherif S. Abdel
    Nomier, Yousra
    Elrebehy, Mahmoud A.
    Elshaer, Shereen Saeid
    Elballal, Mohammed S.
    Mohammed, Osama A.
    Abdel-Reheim, Mustafa Ahmed
    Doghish, Ahmed S.
    [J]. PATHOLOGY RESEARCH AND PRACTICE, 2024, 254
12345