Solar ultraviolet B radiation promotes a-MSH secretion to attenuate the function of ILC2s via the pituitary-lung axis

被引：2

作者：

Huang, Yuying ^{[1
]}

Zhu, Lin ^{[1
]}

Cheng, Shipeng ^{[1
]}

Dai, Ranran ^{[2
]}

Huang, Chunrong ^{[2
]}

Song, Yanyan ^{[3
]}

Peng, Bo ^{[2
]}

Li, Xuezhen ^{[1
]}

Wen, Jing ^{[1
]}

Gong, Yi ^{[4
]}

Hu, Yunqian ^{[5
]}

Qian, Ling ^{[6
]}

Zhu, Linyun ^{[7
]}

Zhang, Fengying ^{[8
]}

Yu, Li ^{[9
]}

Yi, Chunyan ^{[1
]}

Gu, Wangpeng ^{[1
]}

Ling, Zhiyang ^{[1
]}

Ma, Liyan ^{[1
]}

Tang, Wei ^{[2
]}

Peng, Li ^{[10
]}

Shi, Guochao ^{[2
]}

Zhang, Yaguang ^{[1
,11
]}

Sun, Bing ^{[1
]}

机构：

[1] Chinese Acad Sci, State Key Lab Cell Biol, Shanghai Inst Biochem & Cell Biol, Ctr Excellence Mol Cell Sci,Univ Chinese Acad Sci, Shanghai, Peoples R China

[2] Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Dept Pulm & Crit Care Med, Shanghai, Peoples R China

[3] Shanghai Jiao Tong Univ, Sch Med, Clin Res Inst, Dept Biostat, Shanghai, Peoples R China

[4] Fudan Univ, Huashan Hosp, Shanghai, Peoples R China

[5] Tongji Univ, Shanghai East Hosp, Sch Med, Dept Pulm & Crit Care Med, Shanghai, Peoples R China

[6] Fudan Univ, Shanghai Peoples Hosp 5, Dept Pulm & Crit Care Med, Shanghai, Peoples R China

[7] Shanghai Putuo Dist Cent Hosp, Shanghai, Peoples R China

[8] Shanghai Putuo Dist Peoples Hosp, Shanghai, Peoples R China

[9] Tongji Univ, Tongji Hosp, Sch Med, Dept Pulm & Crit Care Med, Shanghai, Peoples R China

[10] Shanghai Meteorol Serv, Shanghai Key Lab Meteorol & Hlth, Shanghai, Peoples R China

[11] Xi An Jiao Tong Univ, Affiliated Hosp 1, Med X Inst, Ctr Immunol & Metab Dis, Xian, Shaanxi, Peoples R China

来源：

NATURE COMMUNICATIONS | 2023年 / 14卷 / 01期

基金：

中国国家自然科学基金;

关键词：

INNATE LYMPHOID-CELLS; ALLERGIC RESPONSES; ADRENAL AXIS; MAST-CELLS; TYPE-2; RECEPTOR; CYTOKINES; IDENTIFICATION; INFLAMMATION; SUPPRESSION;

D O I：

10.1038/s41467-023-41319-1

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The immunomodulatory effects of ultraviolet B (UVB) radiation in human diseases have been described. Whether type 2 lung inflammation is directly affected by solar ultraviolet (UV) radiation is not fully understood. Here, we show a possible negative correlation between solar UVB radiation and asthmatic inflammation in humans and mice. UVB exposure to the eyes induces hypothalamus-pituitary activation and & alpha;-melanocyte-stimulating hormone (& alpha;-MSH) accumulation in the serum to suppress allergic airway inflammation by targeting group 2 innate lymphoid cells (ILC2) through the MC5R receptor in mice. The & alpha;-MSH/MC5R interaction limits ILC2 function through attenuation of JAK/STAT and NF-& kappa;B signaling. Consistently, we observe that the plasma & alpha;-MSH concentration is negatively correlated with the number and function of ILC2s in the peripheral blood mononuclear cells (PBMC) of patients with asthma. We provide insights into how solar UVB radiation-driven neuroendocrine & alpha;-MSH restricts ILC2-mediated lung inflammation and offer a possible strategy for controlling allergic diseases. Allergic asthma is episodic and associated with seasonal changes which may have links with UV exposure levels. Here the authors propose a link between UVB exposure and ILC2 function through & alpha;-MSH released from the pituitary gland which accumulates in the serum and alters ILC2 function through the MC5R receptor.

引用

页数：16

共 1 条

[1] Solar ultraviolet B radiation promotes α-MSH secretion to attenuate the function of ILC2s via the pituitary–lung axis
Yuying Huang
Lin Zhu
Shipeng Cheng
Ranran Dai
Chunrong Huang
Yanyan Song
Bo Peng
Xuezhen Li
Jing Wen
Yi Gong
Yunqian Hu
Ling Qian
Linyun Zhu
Fengying Zhang
Li Yu
Chunyan Yi
Wangpeng Gu
Zhiyang Ling
Liyan Ma
Wei Tang
Li Peng
Guochao Shi
Yaguang Zhang
Bing Sun
Nature Communications, 14

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