mRNA-Based Nanomedicine: A New Strategy for Treating Infectious Diseases and Beyond

被引：3
|
作者：
Prakash, Satyendra [1 ]
机构：
[1] Univ Allahabad, Fac Sci, Ctr Biotechnol, Allahabad, India
来源：
EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS | 2023年 / 48卷 / 05期
关键词：
INTRACELLULAR DELIVERY; HYBRID NANOPARTICLES; LIPID NANOPARTICLES; VACCINES; EFFICIENT; NANOMATERIALS; TRANSLATION; INDUCTION; IMMUNITY; DESIGN;
D O I：
10.1007/s13318-023-00849-1
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Messenger RNA (mRNA) has emerged as a new therapeutic agent for the prevention and treatment of a wide range of diseases. The recent achievement of the two lipid nanoparticle-mRNA vaccines developed by Moderna and Pfizer-BioNTech against coronavirus 2019 (COVID-19) disease in record time highlights the huge potential of mRNA technology and reshaping the landscape of vaccine development and the future of gene therapies. Challenges related to translational efficacy, mRNA stability, immunogenicity, and ensuring the quality of final products have been significantly improved by recent advancements in mRNA engineering and delivery. Thus, the present review aims to provide the latest innovations that incrementally overcome these issues and future directions in the context of ongoing clinical trials against infectious diseases and beyond.
引用
收藏
页码：515 / 529
页数：15
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