Maternal early pregnancy body mass index and bipolar disorder in the offspring

被引:0
|
作者
Beer, Rachael J. [1 ]
Cnattingius, Sven [2 ]
Susser, Ezra S. [3 ]
Wang, Lu [4 ]
Villamor, Eduardo [1 ,5 ]
机构
[1] Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI USA
[2] Karolinska Inst, Div Clin Epidemiol, Dept Med Solna, Stockholm, Sweden
[3] Columbia Univ, New York State Psychiat Inst, Mailman Sch Publ Hlth, Dept Epidemiol, New York, NY USA
[4] Univ Michigan Sch Publ Hlth, Dept Biostat, Dept Biostat, Ann Arbor, MI USA
[5] Univ Michigan, Sch Publ Hlth, Dept Epidemiol, SPH II,1420 Washington Hts, Ann Arbor, MI 48109 USA
关键词
bipolar disorder; maternal body mass index; maternal obesity; maternal overweight; PSYCHIATRIC-DISORDERS; MEDIATION ANALYSIS; ANXIETY DISORDERS; PLACENTAL SIZE; WEIGHT-GAIN; RISK-FACTOR; OBESITY; PREPREGNANCY; POPULATION; CHILDHOOD;
D O I
10.1111/bdi.13399
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
ObjectivesTo investigate the association between maternal early pregnancy body mass index (BMI) and offspring bipolar disorder (BPD).MethodsWe conducted a nationwide cohort study among 1,507,056 non-malformed singleton live-births in Sweden born 1983-2004. Using national registries with prospectively recorded information, we followed participants for a BPD diagnosis from ages 13 to up to 35 years. We compared BPD risks by early pregnancy BMI using hazard ratios (HR) with 95% confidence intervals (CI) from adjusted Cox models. We also conducted sibling-controlled analyses among 874,047 full siblings.ResultsThere were 9970 BPD diagnoses. Risk of BPD was 0.72% through 25 years of age. Maternal early pregnancy BMI was positively associated with offspring BPD risk. Compared with normal BMI (18.5-24.9), adjusted HR (95% CI) for overweight (BMI 25-29.9), obesity grade 1 (BMI 30-34.9), and obesity grades 2-3 (BMI >= 35) were 1.08 (1.02, 1.15), 1.26 (1.14, 1.40), and 1.31 (1.07, 1.60), respectively. Adjusted HR per unit BMI was 1.015 (95% CI 1.009, 1.021). A similar trend was observed among siblings. Pregnancy and neonatal complications did not substantially mediate the association between maternal obesity (BMI >= 30) and offspring BPD.ConclusionsMaternal BMI >= 25 is associated with offspring BPD risk in a dose-response manner.
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收藏
页码:348 / 355
页数:8
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