Autoimmune Pulmonary Alveolar Proteinosis That Improved after a COVID-19 Episode

被引：1

作者：

Yanagisawa, Atsushi

Takimoto, Takayuki

Shintani, Ryota

Kobayashi, Takehiko

Hirose, Masaki

Arai, Toru ^{[1
]}

Inoue, Yoshikazu

机构：

[1] Natl Hosp Org Kinki Chuo Chest Med Ctr, Dept Internal Med, Sakai, Japan

来源：

INTERNAL MEDICINE | 2023年 / 62卷 / 15期

关键词：

pulmonary alveolar proteinosis; coronavirus disease 2019 (COVID-19); viral infection; granulocyte -macrophage colony-stimulating factor (GM-CSF); GM-CSF; DISEASE; REMISSION;

D O I：

10.2169/internalmedicine.1592-23

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Autoimmune pulmonary alveolar proteinosis (APAP) is caused by macrophage dysfunction owing to the presence of anti-granulocyte-macrophage colony-stimulating factor (GM-CSF) autoantibodies. A 77-year-old man with APAP was referred to our hospital for whole-lung lavage (WLL) due to oxygenation exacerbation and pulmonary shadows. The patient had had coronavirus disease 2019 (COVID-19) during the APAP evaluation before WLL. About three months after COVID-19 resolved, his oxygenation and shadow reflecting APAP had obviously improved, thus avoiding the need for WLL. We suspected that the improvement in APAP was due to various immunological reactions induced by COVID-19.

引用

页码：2237 / 2241

页数：5

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