MRGPRX2 Small Molecule Antagonists Potently Inhibit Agonist-Induced Skin Mast Cell Degranulation

被引:0
|
作者
Frischbutter, S. [1 ]
Wollam, J. [2 ]
Solomon, M. [2 ]
Villescaz, C. [2 ]
Evans, S. [2 ]
Freeman, D. [2 ]
Vasquez, A. [2 ]
Pisacane, C. [2 ]
Vest, A. [2 ]
Napora, J. [2 ]
Charlot, B. [2 ]
Cavarlez, C. [2 ]
Kim, A. [2 ]
Viswanath, V. [2 ]
Metz, M. [1 ]
机构
[1] Charite Univ Med Berlin, Inst Allergol, D-12203 Berlin, Germany
[2] Fraunhofer Inst Translat Med & Pharmacol ITMP, Immunol & Allergol, D-12203 Berlin, Germany
关键词
D O I
暂无
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
P176
引用
收藏
页数:1
相关论文
共 39 条
  • [1] MRGPRX2 small molecule antagonists potently inhibit agonist-induced skin mast cell degranulation
    Wollam, J.
    Solomon, M.
    Villescaz, C.
    Anderson, S.
    Freeman, D.
    Vasquez, A.
    Pisacane, C.
    Vest, A.
    Napora, J.
    Charlot, B.
    Cavarlez, C.
    Kim, A.
    Dvorak, L.
    Lanier, M.
    Selfridge, B.
    Huang, L.
    Saenz, M.
    Brooks, J.
    Nevarez, A.
    Dedman, H.
    Timony, G.
    Martinborough, E.
    Viswanath, V.
    Boehm, M.
    ALLERGY, 2023, 78 : 204 - 204
  • [2] MRGPRX2 Small Molecule Antagonists Potently Inhibit Agonist-Induced Skin Mast Cell Degranulation
    Wollam, Joshua
    Solomon, Michelle
    Villescaz, Christiane
    Evans, Samantha
    Freeman, David
    Bacon, Corinne
    Frischbutter, Stefan
    Metz, Martin
    Vest, Alan
    Napora, Jim
    Charlot, Brittney
    Cavarlez, Christine
    Kim, Andrew
    Viswanath, Veena
    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2024, 153 (02) : AB62 - AB62
  • [3] Inhibition of mast cell degranulation by novel small molecule MRGPRX2 antagonists
    Wollam, Joshua
    Solomon, Michelle
    Villescaz, Christiane
    Lanier, Marion
    Evans, Samantha
    Bacon, Corinne
    Freeman, David
    Vasquez, Alexis
    Vest, Alan
    Napora, Jim
    Charlot, Brittney
    Cavarlez, Christine
    Kim, Andrew
    Dvorak, Lisa
    Selfridge, Brandon
    Huang, Liming
    Nevarez, Andres
    Dedman, Harry
    Brooks, Jennifer
    Frischbutter, Stefan
    Metz, Martin
    Serhan, Nadine
    Gaudenzio, Nicolas
    Timony, Gregg
    Martinborough, Esther
    Boehm, Marcus F.
    Viswanath, Veena
    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2024, 154 (04) : 1033 - 1043
  • [4] MRGPRX2 Antagonist EP262 Potently Inhibits Agonist-Induced Mast Cell Degranulation In Vitro and In Vivo
    Wollam, Joshua
    Solomon, Michelle
    Villescaz, Christiane
    Lanier, Marion
    Brooks, Jennifer
    Kim, Andrew
    Anderson, Samantha
    Freeman, David
    Vasquez, Alexis
    Pisacane, Corinne
    Charlot, Brittney
    Vest, Alan
    Napora, Jim
    Cavarlez, Christine
    Dvorak, Lisa
    Selfridge, Brandon
    Huang, Liming
    Sainz, Marcos
    Nevarez, Andres
    Dedman, Harry
    Timony, Gregg
    Martinborough, Esther
    Viswanath, Veena
    Boehm, Marcus
    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2023, 151 (02) : AB203 - AB203
  • [5] Inhibition of MRGPRX2 but not FcεRI or MrgprB2-mediated mast cell degranulation by a small molecule inverse receptor agonist
    Bawazir, Maram
    Amponnawarat, Aetas
    Hui, Yvonne
    Oskeritzian, Carole A.
    Ali, Hydar
    FRONTIERS IN IMMUNOLOGY, 2022, 13
  • [6] Novel small molecule MRGPRX2 antagonists inhibit a murine model of allergic reaction
    Kumar, Mukesh
    Duraisamy, Karthi
    Annapureddy, Rajasekar Reddy
    Chan, Chi Bun
    Chow, Billy K. C.
    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2023, 151 (04) : 1110 - 1122
  • [7] FcεRI and MRGPRX2 differentially regulate mast cell degranulation dynamics
    Gaudenzio, N.
    REVUE FRANCAISE D ALLERGOLOGIE, 2018, 58 (02): : 101 - 105
  • [8] CREB Is Critically Implicated in Skin Mast Cell Degranulation Elicited via FcεRI and MRGPRX2
    Li, Zhuoran
    Schneikert, Jean
    Tripathi, Shiva Raj
    Jin, Manqiu
    Bal, Guerkan
    Zuberbier, Torsten
    Babina, Magda
    CELLS, 2024, 13 (20)
  • [9] Mast cell degranulation via MRGPRX2 by isolated human albumin fragments
    Karhu, T.
    Akiyama, K.
    Vuolteenaho, O.
    Bergmann, U.
    Naito, T.
    Tatemoto, K.
    Herzig, K. -H.
    BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2017, 1861 (11): : 2530 - 2534
  • [10] Neuromedin U directly induces degranulation of skin mast cells, presumably via MRGPRX2
    Matsuo, Yoshimi
    Yanase, Yuhki
    Irifuku, Reiko
    Takahagi, Shunsuke
    Mihara, Shoji
    Ishii, Kaori
    Kawaguchi, Tomoko
    Tanaka, Akio
    Iwamoto, Kazumasa
    Watanuki, Haruka
    Furuta, Kazuyuki
    Tanaka, Satoshi
    Inoue, Asuka
    Aoki, Junken
    Hide, Michihiro
    ALLERGY, 2018, 73 (11) : 2256 - 2260