Anti-SARS-CoV-2 antibody kinetics up to 6 months of follow-up: Result from a nation-wide population-based, age stratified sero-epidemiological prospective cohort study in India

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作者
Misra, Puneet [1 ]
Singh, Arvind Kumar [2 ]
Mishra, Baijayantimala [3 ]
Behera, Bijayini [2 ]
Patro, Binod Kumar [2 ]
Medigeshi, Guruprasad R. [4 ]
Joshi, Hari Shanker [5 ]
Ahmad, Mohammad [6 ]
Chaturvedi, Pradeep Kumar [7 ]
Chinnakali, Palanivel [8 ]
Haldar, Partha [1 ]
Bairwa, Mohan [1 ]
Kharya, Pradeep [5 ]
Dhodapkar, Rahul [9 ]
Rath, Ramashankar [5 ]
Guleria, Randeep [10 ]
Rai, Sanjay Kumar [1 ]
Kar, Sitanshu Sekhar [8 ]
Kant, Shashi [1 ]
Sarkar, Sonali [8 ]
Baidya, Subrata [11 ]
Meena, Suneeta [12 ]
Mandal, Suprakash [1 ]
Kishore, Surekha [13 ]
Majumder, Tapan [14 ]
Hada, Vivek [15 ]
机构
[1] All India Inst Med Sci, Ctr Community Med, New Delhi, India
[2] All India Inst Med Sci, Dept Community & Family Med, Bhubaneswar, Odisha, India
[3] All India Inst Med Sci, Dept Microbiol, Bhubaneswar, Odisha, India
[4] Translat Hlth Sci & Technol Inst, Faridabad, India
[5] All India Inst Med Sci, Dept Community & Family Med, Gorakhpur, India
[6] WHO, WHO Country Off, New Delhi, India
[7] All India Inst Med Sci, Dept Reprod Biol, New Delhi, India
[8] Jawaharlal Inst Postgrad Med Educ & Res, Dept Community Med, Pondicherry, India
[9] Jawaharlal Inst Postgrad Med Educ & Res, Dept Microbiol, Pondicherry, India
[10] All India Inst Med Sci, New Delhi, India
[11] Agartala Govt Med Coll, Dept Community Med, Agartala, India
[12] All India Inst Med Sci, Dept Lab Med, New Delhi, India
[13] All India Inst Med Sci, Gorakhpur, India
[14] Agartala Govt Med Coll, Dept Microbiol, Agartala, India
[15] All India Inst Med Sci, Dept Microbiol, Gorakhpur, Uttar Pradesh, India
来源
PLOS ONE | 2023年 / 18卷 / 12期
关键词
D O I
10.1371/journal.pone.0287807
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Repeated serological testing tells about the change in the overall infection in a community. This study aimed to evaluate changes in antibody prevalence and kinetics in a closed cohort over six months in different sub-populations in India. The study included 10,000 participants from rural and urban areas in five states and measured SARS-CoV-2 antibodies in serum in three follow-up rounds. The overall seroprevalence increased from 73.9% in round one to 90.7% in round two and 92.9% in round three. Among seropositive rural participants in round one, 98.2% remained positive in round two, and this percentage remained stable in urban and tribal areas in round three. The results showed high antibody prevalence that increased over time and was not different based on area, age group, or sex. Vaccinated individuals had higher antibody prevalence, and nearly all participants had antibody positivity for up to six months.
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页数:10
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