Oncolytic Reoviruses: Can These Emerging Zoonotic Reoviruses Be Tamed and Utilized?

被引：8
|
作者：
Siew, Zhen Yun [1 ]
Loh, Alson [2 ]
Segeran, Sharrada [3 ]
Leong, Pooi Pooi [4 ]
Voon, Kenny [1 ]
机构：
[1] Univ Nottingham Malaysia, Sch Pharm, Semenyih, Malaysia
[2] Int Med Univ, Sch Postgrad Studies, Kuala Lumpur, Malaysia
[3] Australian Natl Univ, Sch Med, Canberra, Australia
[4] Univ Tunku Abdul Rahman, Fac Med & Hlth Sci, Kajang, Malaysia
来源：
DNA AND CELL BIOLOGY | 2023年 / 42卷 / 06期
关键词：
oncolytic virus; reovirus; orthoreovirus; virotherapy; pelareorep; zoonotic spillover; REVERSE GENETICS SYSTEM; SIGMA-NS PROTEIN; AVIAN REOVIRUS; MAMMALIAN ORTHOREOVIRUS; FRUIT BATS; PTEROPINE-ORTHOREOVIRUS; INDUCED APOPTOSIS; GENOME SEGMENTS; SIALIC-ACID; CATHEPSIN-L;
D O I：
10.1089/dna.2022.0561
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Orthoreovirus is a nonenveloped double-stranded RNA virus under the Reoviridae family. This group of viruses, especially mammalian orthoreovirus (MRV), are reported with great therapeutic values due to their oncolytic effects. In this review, the life cycle and oncolytic effect of MRV and a few emerging reoviruses were summarized. This article also highlights the challenges and strategies of utilizing MRV and the emerging reoviruses, avian orthoreovirus (ARV) and pteropine orthoreovirus (PRV), as oncolytic viruses (OVs). Besides, the emergence of potential ARV and PRV as OVs were discussed in comparison to MRV. Finally, the risk of reovirus as zoonosis or reverse zoonosis (zooanthroponosis) were debated, and concerns were raised in this article, which warrant continue surveillance of reovirus (MRV, ARV, and PRV) in animals, humans, and the environment.
引用
收藏
页码：289 / 304
页数：16
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