Increase in invasive group A streptococcal infections and emergence of novel, rapidly expanding sub-lineage of the virulent Streptococcus pyogenes M1 clone, Denmark, 2023

被引：47

作者：

Johannesen, Thor Bech ^{[1
]}

Munkstrup, Charlotte ^{[2
]}

Edslev, Sofie Marie ^{[1
]}

Baig, Sharmin ^{[1
]}

Nielsen, Stine ^{[2
]}

Funk, Tjede ^{[2
]}

Kristensen, Dennis Karsten ^{[3
]}

Jacobsen, Lars Hervig ^{[3
]}

Ravn, Signe Fischer ^{[3
]}

Bindslev, Niels ^{[3
]}

Gubbels, Sophie ^{[3
]}

Voldstedlund, Marianne ^{[3
]}

Jokelainen, Pikka ^{[4
]}

Hallstrom, Soren ^{[1
]}

Rasmussen, Astrid ^{[1
]}

Kristinsson, Karl Gustaf ^{[5
,6
]}

Fuglsang-Damgaard, David ^{[7
]}

Dessau, Ram B. ^{[8
,9
]}

Olsen, Agnieszka Barbara ^{[10
]}

Jensen, Christian Salgaard ^{[11
]}

Skovby, Annette ^{[12
]}

Ellermann-Eriksen, Svend ^{[13
]}

Jensen, Thoger Gorm ^{[14
,15
]}

Dzajic, Esad ^{[16
]}

Ostergaard, Claus ^{[17
]}

Andersen, Steen Lomborg ^{[18
]}

Hoffmann, Steen ^{[1
]}

HenrikAndersen, Peter ^{[2
]}

Stegger, Marc ^{[1
,19
]}

机构：

[1] Statens Serum Inst, Bacteria Parasites & Fungi, Copenhagen, Denmark

[2] Statens Serum Inst, Infect Dis Epidemiol & Prevent, Copenhagen, Denmark

[3] Statens Serum Inst, Data Integrat & Anal, Copenhagen, Denmark

[4] Statens Serum Inst, Infect Dis Preparedness, Copenhagen, Denmark

[5] Landspitali Natl Univ Hosp, Dept Clin Microbiol, Reykjavik, Iceland

[6] Univ Iceland, Fac Med, Reykjavik, Iceland

[7] Aalborg Univ Hosp, Dept Clin Microbiol, Aalborg, Denmark

[8] Zealand Univ Hosp, Dept Clin Microbiol, Slagelse, Denmark

[9] Univ Southern Denmark, Dept Reg Hlth Res, Odense, Denmark

[10] Univ Hosp, Herlev & Gentofte Hosp, Dept Clin Microbiol, Herlev, Denmark

[11] Rigshosp, Dept Clin Microbiol, Copenhagen, Denmark

[12] Copenhagen Univ Hosp Amager & Hvidovre, Hvidovre, Denmark

[13] Aarhus Univ Hosp, Dept Clin Microbiol, Aarhus, Denmark

[14] Odense Univ Hosp, Dept Clin Microbiol, Odense, Denmark

[15] Res Unit Clin Microbiol, Odense, Denmark

[16] Univ Hosp Southern Denmark, Hosp South West Jutland, Clin Diagnost Dept, Clin Microbiol, Esbjerg, Denmark

[17] Univ Hosp Southern Denmark, Lillebaelt Hosp, Dept Clin Microbiol, Vejle, Denmark

[18] Univ Hosp Southern Denmark, Sonderjylland Hosp, Dept Clin Microbiol, Aabenraa, Denmark

[19] Murdoch Univ, Harry Butler Inst, Antimicrobial Resistance & Infect Dis Lab, Perth, Australia

来源：

EUROSURVEILLANCE | 2023年 / 28卷 / 26期

关键词：

Denmark; Iceland; M1; M1DK; Streptococcus pyogenes; bacterial genomics; group A Streptococcus; virulence;

D O I：

10.2807/1560-7917.ES.2023.28.26.2300291

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

A highly virulent sub-lineage of the Streptococcus pyogenes M1 clone has been rapidly expanding throughout Denmark since late 2022 and now accounts for 30% of the new invasive group A streptococcal infections. We aimed to investigate whether a shift in variant composition can account for the high incidence rates observed over winter 2022/23, or if these are better explained by the impact of COVID-19-related restrictions on population immunity and carriage of group A Streptococcus.

引用

页数：6

共 4 条

[1] Increase in invasive Streptococcus pyogenes M1 infections with close evolutionary genetic relationship, Iceland and Scotland, 2022 to 2023
Beres, Stephen B.
Olsen, Randall J.
Long, S. Wesley
Langley, Ross
Williams, Thomas
Erlendsdottir, Helga
Smith, Andrew
Kristinsson, Karl G.
Musser, James M.
EUROSURVEILLANCE, 2024, 29 (13)
[2] Emergence and spread of a new clone of M type 1 group A Streptococcus coincident with the increase in invasive diseases in Japan
Murono, K
Fujita, K
Saijo, A
Hirano, Y
Zhang, JW
Murai, T
PEDIATRIC INFECTIOUS DISEASE JOURNAL, 1999, 18 (03) : 254 - 257
[3] Sustained increase of paediatric invasive Streptococcus pyogenes infections dominated by M1UK and diverse emm12 isolates, Portugal, September 2022 to May 2023
Gouveia, Catarina
Bajanca-Lavado, Maria Paula
Mamede, Rafael
Carvalho, Ana Araujo
Rodrigues, Fernanda
Melo-Cristino, Jose
Ramirez, Mario
Friaes, Ana
EUROSURVEILLANCE, 2023, 28 (36)
[4] Increase in bloodstream infections caused by emm1 group A Streptococcus correlates with emergence of toxigenic M1UK, Belgium, May 2022 to August 2023
Rodriguez-Ruiz, Juan Pablo
Lin, Qiang
Lammen, Christine
Smeesters, Pierre R.
van Kleef-van Koeveringe, Stefanie
Matheeussen, Veerle
Malhotra-Kumar, Surbhi
EUROSURVEILLANCE, 2023, 28 (36)

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