Indications of Endocrine Disruptor Effects of JP-5 Jet Fuel Using a Rat-Model Reproductive Study and an In Vitro Human Hormone Receptor Assay

被引：0

作者：

Howard, William R. ^{[1
]}

Rohan, Joyce G. ^{[1
]}

Yeager, Kimberly S. B. ^{[1
,2
]}

Gut, Chester P. ^{[1
,3
]}

Frondorf, Kathleen A. ^{[1
,3
]}

Mcinturf, Shawn M. ^{[1
]}

Gargas, Nathan M. ^{[1
]}

Mumy, Karen L. ^{[1
]}

机构：

[1] Naval Med Res Unit Dayton, Dayton, OH 45433 USA

[2] Abbott Labs, Columbus, OH 43219 USA

[3] Reston Town Ctr, 1750 Presidents St, Reston, VA 20190 USA

来源：

TOXICS | 2024年 / 12卷 / 03期

关键词：

jet fuel; jet propellant; JP-5; JP-8; estrogen receptor; endocrine disruptor; EXPOSURE; ESTROGENS; PATHWAYS;

D O I：

10.3390/toxics12030220

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Recent events concerning jet fuel contamination of drinking water have shown that we need a better understanding of the effects of ingested jet fuel. To this end, a reproductive study with ingested jet fuel in rats was undertaken with relatively high concentrations of Jet Propellant (JP)-5 along with a human estrogen receptor activation in vitro assay using JP-5, JP-8, and an alternative jet fuel derived from the camelina plant referred to as HydroRenewable Jet (HRJ) fuel, to help evaluate potential effects of ingested jet fuel. The results of the in vivo study provide evidence that JP-5 can act as an endocrine disruptor, with specific observations including altered hormone levels with JP-5 exposure (significantly lower estradiol levels in male rats and significantly increased Dehydroepiandrosterone levels in females), and a decreased male/female offspring ratio. The in vitro hormone receptor activation assay indicated that JP-5 and JP-8 are capable of upregulating human estrogen receptor (ER) activity, while HRJ was not active in the ER assay. The jet fuels were not able to activate androgen or glucocorticoid receptors in further in vitro assays. These results infer potential endocrine disruption associated with JP-5, with activation of the estrogen receptor as one potential mechanism of action.

引用

页数：27