Genetic Predisposition to Neurological Complications in Patients with COVID-19

被引：0

作者：

Sahajpal, Nikhil Shri ^{[1
,2
]}

Hastie, Alex R. R. ^{[3
]}

Schieck, Maximilian ^{[4
,5
]}

Mondal, Ashis K. K.

Felde, Marc ^{[6
]}

van der Made, Caspar I. I. ^{[7
,8
,9
]}

Chou, Janet S. S.

Randolph, Adrienne G. G. ^{[10
,11
,12
]}

Illig, Thomas ^{[4
,5
]}

Zody, Michael C. C. ^{[13
]}

Brownstein, Catherine A. A.

Beggs, Alan H. H.

Hoischen, Alexander ^{[7
,8
,9
]}

Chaubey, Alka ^{[3
]}

Kolhe, Ravindra ^{[1
]}

机构：

[1] Augusta Univ, Med Coll Georgia, Dept Pathol, Augusta, GA 30912 USA

[2] Greenwood Genet Ctr, Greenwood, SC 29646 USA

[3] Bionano Genom Inc, San Diego, CA 92121 USA

[4] Hannover Med Sch, Hannover Unified Biobank, D-30625 Hannover, Germany

[5] Hannover Med Sch, RESIST Cluster Excellence 2155, D-30625 Hannover, Germany

[6] Hannover Med Sch, Dept Human Genet, D-30625 Hannover, Germany

[7] Radboud Univ Med Ctr Infect Dis RCI, Dept Human Genet, NL-6525 Nijmegen, Netherlands

[8] Radboud Univ Nijmegen, Med Ctr, Radboud Inst Mol Life Sci, Dept Internal Med, NL-6525 Nijmegen, Netherlands

[9] Radboud Univ Nijmegen, Med Ctr, Radboud Expertise Ctr Immunodeficiency & Autoinfla, NL-6525 Nijmegen, Netherlands

[10] Harvard Med Sch, Boston Childrens Hosp, Manton Ctr Orphan Dis Res, Dept Anesthesiol Crit Care & Pain Med, Boston, MA 02115 USA

[11] Harvard Med Sch, Dept Anesthesia, Boston, MA 02115 USA

[12] Harvard Med Sch, Dept Pediat, Boston, MA 02115 USA

[13] New York Genome Ctr, New York, NY 10013 USA

来源：

BIOMOLECULES | 2023年 / 13卷 / 01期

关键词：

optical genome mapping; COVID-19; neurological complications; rare SVs; genetic predisposition; PARKINSONS-DISEASE; CEREBELLAR-ATAXIA; MUTATIONS;

D O I：

10.3390/biom13010133

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Several studies have identified rare and common genetic variants associated with severe COVID-19, but no study has reported genetic determinants as predisposition factors for neurological complications. In this report, we identified rare/unique structural variants (SVs) implicated in neurological functions in two individuals with neurological manifestations of COVID-19. This report highlights the possible genetic link to the neurological symptoms with COVID-19 and calls for a collective effort to study these cohorts for a possible genetic linkage.

引用

页数：11

共 50 条

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Rojo Moreno-Arrones, B.
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