Rh(III)-Catalyzed Dienylation and Cyclopropylation of 1,2,3-Benzotriazinones with Alkylidenecyclopropanes

被引：5

作者：

Liu, Yan-Zhi ^{[1
]}

Zeng, Yao-Fu ^{[3
]}

Wei, Jiaohang ^{[1
]}

Xiao, Lin ^{[1
]}

Shu, Bing ^{[2
]}

Song, Jia-Lin ^{[1
]}

Zou, Wen-Xuan ^{[1
]}

Shen, Dan-Ting ^{[1
]}

Chen, Shao-Yong ^{[1
]}

Zheng, Yi-Chuan ^{[1
]}

Zhang, Shang-Shi ^{[1
]}

机构：

[1] Guangdong Pharmaceut Univ, Ctr Drug Res & Dev, Guangdong Prov Engn Ctr Top Precise Drug Delivery, Guangdong Prov Key Lab Adv Drug Delivery, R China, Guangzhou 510006, Peoples R China

[2] Guangdong Pharmaceut Univ, Sch Pharm, Guangzhou 510006, Peoples R China

[3] Univ South China, Sch Pharmaceut Sci, Hunan Prov Key Lab Tumor Microenvironm Respons Dru, Hengyang 421001, Hunan, Peoples R China

来源：

ORGANIC LETTERS | 2023年 / 25卷 / 28期

基金：

中国国家自然科学基金;

关键词：

C-H ACTIVATION; CATALYZED DENITROGENATIVE ANNULATION; ALKYNE INSERTION; METHYLENECYCLOPROPANES; BENZOTRIAZINONES; HYDROARYLATIONS;

D O I：

10.1021/acs.orglett.3c01596

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Rh (III)-catalyzed dienylation and cyclopropylation of1,2,3-benzotriazinoneswith alkylidenecyclopropanes (ACPs) has been achieved. Different fromthe previous reports of 1,2,3-benzotriazinones, the triazinone ringremained intact in this C-H bond functionlization reaction.Also, the denitrogenative cyclopropylation could also be realizedby changing the reaction temperature. This protocol is featured withhigh E selectivity, wide substrate scope, and divergentstructures of products.

引用

页码：5179 / 5184

页数：6

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