Acylphloroglucinol-monoterpene meroterpenoids from Eucalyptus tereticornis and their inhibitory activity against ATP citrate lyase

被引：8
|
作者：
Li, Jin-Sheng [1 ]
Liu, Yi-Nan [1 ,3 ]
Li, Jing-Ya [3 ,4 ]
Lei, Chun [1 ]
Hou, Ai-Jun [1 ,2 ]
机构：
[1] Fudan Univ, Sch Pharm, Shanghai 201203, Peoples R China
[2] Shanghai Jiao Tong Univ, Sch Pharm, Shanghai 200240, Peoples R China
[3] Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
[4] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
来源：
PHYTOCHEMISTRY | 2023年 / 207卷
基金：
中国国家自然科学基金;
关键词：
Eucalyptus tereticornis Smith; Myrtaceae; Meroterpenoids; (-)-eucateretins A-E; ATP citrate Lyase; FORMYL-PHLOROGLUCINOL MEROTERPENOIDS; BIOMIMETIC SYNTHESIS; ENANTIOMERIC PAIRS; ROBUSTADIAL-A; LEAVES; EUGLOBAL-G3;
D O I：
10.1016/j.phytochem.2022.113565
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Five undescribed enantiomeric pairs of acylphloroglucinol-monoterpene meroterpenoids ((+)-/(-)-eucateretins A-E) resolved by chiral-phase HPLC were obtained from the leaves of Eucalyptus tereticornis Smith, along with nine known analogues. Their structures were elucidated by spectroscopic methods and ECD calculations. This is the first report of meroterpenoid enantiomers from this plant. Some of the isolates, (-)-eucateretin A, (+)-/(-)-eucateretins E, 7 'alpha-eucalrobusone X, eucalrobusone X, and robustadial B, exhibited inhibitory effects on ATP citrate lyase, and 7 'alpha-eucalrobusone X significantly suppressed the hepatocyte lipogenesis.
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页数：7
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