Potentiometric determination of mephedrone in oral fluids with ion-selective membranes

被引：5
|
作者：
Pospisilova, Eva [1 ]
Paskanova, Natalie [2 ]
Kuchar, Martin [2 ]
Shishkanova, Tatiana V. [1 ]
机构：
[1] Univ Chem & Technol, Dept Analyt Chem, Tech 5, Prague 6, Czech Republic
[2] Univ Chem & Technol, Dept Chem Nat Cpds, Forens Lab Biol Act Subst, Tech 3, Prague, Czech Republic
来源：
ELECTROANALYSIS | 2023年 / 35卷 / 06期
关键词：
ion-selective membranes; oral fluid; potentiometry; synthetic cathinones; SYNTHETIC CATHINONES; ELECTRODES; COEFFICIENTS; CALIXARENES; VALIDATION; CATIONS; SENSORS; BINDING; SALIVA;
D O I：
10.1002/elan.202200468
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
This work presents a potentiometric approach for the detection of two cathinone derivatives, namely mephedrone (4-MMC) and clephedrone (4-CMC). Contrary to neutral-carriers (dibenzo-18-crown-6-ether and calix[4]arene), cation-exchanger (tetraphenylborate sodium) as active component of ion-selective membrane showed near-Nernstian response (+47 mV/decade from 1.7 center dot 10(-6) to 5.6 center dot 10(-4) mol l(-1)) and selectivity for 4-MMC in oral fluids (OF). The agreement between the quantitative results obtained with the potentiometric approach and the HPLC/MS-MS method determination of 4-MMC in OF shows the potential of the proposed potentiometric approach for forensic analysis.
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页数：8
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