Effect of short-term plasticity on working memory

被引:0
|
作者
Yang, Fan
Liu, Feng [1 ]
机构
[1] Nanjing Univ, Dept Phys, Nanjing 210093, Peoples R China
关键词
bump attractor; synaptic plasticity; robustness; sensitivity; 87.19.lj; 87.19.lw; 87.18.Sn; PREFRONTAL-CORTEX; SYNAPTIC MECHANISMS; PERSISTENT ACTIVITY; FACILITATION; SYNAPSES; ACCURACY; NETWORK;
D O I
10.1088/1674-1056/acf03a
中图分类号
O4 [物理学];
学科分类号
0702 ;
摘要
The way in which persistent firing activity and synaptic plasticity are orchestrated to underlie working memory in recurrent neural networks is not fully understood. Here, we build a continuous attractor network of pyramidal cells and interneurons to simulate an oculomotor delayed response task. Both short-term facilitation (STF) and short-term depression (STD) manifest at synapses between pyramidal cells. The efficacy of individual synapses depends on the time constants of STF and STD as well as the presynaptic firing rate. Self-sustained firing activity (i.e., a bump attractor) during the delay period encodes the cue position. The bump attractor becomes more robust against random drifts and distractions with enhancing STF or reducing STD. Keeping STF and STD at appropriate levels is crucial for optimizing network performance. Our results suggest that, besides slow recurrent excitation and strong global inhibition, short-term plasticity plays a prominent role in facilitating mnemonic behavior.
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页数:8
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