Nicotinamide mononucleotide (NMN) ameliorated Nonylphenol-induced learning and memory impairment in rats via the central 5-HT system and the NAD+/SIRT1/MAO-A pathway

被引：5

作者：

Huang, Huiying ^{[1
,2
]}

Shi, Jian ^{[1
,2
]}

Li, Zhongyi ^{[1
,2
]}

Rang, Yifeng ^{[1
,2
]}

Li, Weiye ^{[1
,2
]}

Xiao, Xueman ^{[1
,2
]}

Chen, Congying ^{[1
,2
]}

Liu, Chunhong ^{[1
,2
]}

机构：

[1] South China Agr Univ, Coll Food Sci, Guangzhou 510642, Peoples R China

[2] Guangdong Prov Key Lab Food Qual & Safety, Guangzhou 510642, Peoples R China

来源：

FOOD AND CHEMICAL TOXICOLOGY | 2023年 / 178卷

关键词：

Nicotinamide mononucleotide; Nonylphenol; Learning and memory; Central 5-HT system; INDUCED COGNITIVE IMPAIRMENT; EXPOSURE; RECEPTOR; SIRT1; TRANSCRIPTION; BIOSYNTHESIS; EXPRESSION; APOPTOSIS; BRAIN;

D O I：

10.1016/j.fct.2023.113878

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Nonylphenol (NP) exposure can trigger neurotoxicity and cause learning and memory impairment. Nicotinamide mononucleotide (NMN) has a therapeutic effect on neurodegenerative diseases, but the role of NMN on NPinduced learning and memory impairment is not known. Here, we examined the mitigative effect of NMN on the impaired learning and memory ability of rats exposed to NP. The NP impaired learning and memory in rats, while the low-dose intervention with NMN significantly prolonged the step-through latency of the PAT and improved the NAMPT and NMNAT1 content in brain tissue. At the same time, the NMN intervention also increased the content of 5-HTR1A, 5-HTR4, and 5-HTR6 related to learning and memory in the hippocampus. In line with this, we found that the NMN intervention activated the SIRT1/MAO-A pathway in brain tissue. NMN intervention, especially at 125 mg/kg doses, may improve rats' NP-induced learning and memory impairment via the central 5-HT system and the NAD+/SIRT1/MAO-A pathway in the brain.

引用

页数：8