Two-dimensional (2D) transition metal carbon/nitride (MXene) is a new group of 2D nanomaterial with excellent electrical, mechanical properties, as well as the rich and tunable surface chemistry, which has received wide attention in functional materials. In addition, MXene can be dispersed in a variety of solvents to form high-concentration dispersions and exhibits nematic liquid crystal properties, which exhibit nematic liquid crystal properties above a critical concentration, allowing for the preparation of macroscopically continuous fiber by wet spinning process. Until now, MXene fibers have exhibited high electrical/thermal conductivity, mechanical strength, and other properties, showing promising potential for the development of the new generation of wearable electronics. This review first introduces MXene materials and their preparation methods, followed by four common methods of fiber spinning. Then, the development of pure MXene fibers and MXene-based composite fibers is summarized. Finally, the possible future directions and challenges of wet-spun MXene-based fibers are concluded, which may provide reference ideas for the future research of MXenes.