Potent in Vitro and In Vivo Efficacy of BYON4413, a Duba-Based Antibody-Drug Conjugate Targeting CD123 in Acute Myeloid Leukemia

被引:3
|
作者
van der Lee, Miranda [1 ]
van Achtenberg, Tanja [1 ]
Brouwers-Vos, Annet [2 ]
van der Vleuten, Monique [1 ]
Kappers, Wendy [1 ]
Verheijden, Gijs [1 ]
Huls, Geert A. [3 ]
van Wigcheren, Glenn [1 ]
Ubink, Ruud [1 ]
Sesink, Aloys [1 ]
MacInnes, Alyson [1 ]
Schuringa, Jan Jacob [4 ]
Dokter, Wim [1 ]
机构
[1] Byondis BV, Nijmegen, Netherlands
[2] Univ Groningen, Univ Med Ctr Groningen, Groningen, Netherlands
[3] Univ Med Ctr Groningen, Groningen, Netherlands
[4] Univ Med Ctr Groningen, Dept Expt Hematol, Groningen, Netherlands
关键词
D O I
10.1182/blood-2023-177622
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页数:2
相关论文
共 50 条
  • [1] BYON4413, an in vivo active CD123-targeting antibody-drug conjugate, combines effectively with azacitidine and venetoclax in acute myeloid leukemia cell lines
    van der Lee, Miranda M. C.
    van Achterberg, Tanja
    Hersmus, Kaylee
    Brouwers-Vos, Annet
    van der Vleuten, Monique
    Pruis, Maurien
    Kappers, Wendy
    Verheijden, Gijs
    Huls, Gerwin
    van Wigcheren, Glenn
    Ubink, Ruud
    Sesink, Aloys
    MacInnes, Alyson
    Schuringa, Jan Jacob
    Dokter, Wim
    CANCER RESEARCH, 2024, 84 (06)
  • [2] VIP943 Is a Novel CD123 Antibody Drug Conjugate with in Vitro and In Vivo Efficacy in Acute Myeloid Leukemia (AML) Models
    Stelte-Ludwig, Beatrix
    Clemens, George
    Schomber, Tibor
    Frigault, Melanie M.
    Johnson, Amy J.
    Lerchen, Hans-Georg
    Izumi, Raquel
    Hamdy, Ahmed
    BLOOD, 2022, 140 : 5955 - 5956
  • [3] CD123 expression patterns and selective targeting with a CD123-targeted antibody-drug conjugate (IMGN632) in acute lymphoblastic leukemia
    Angelova, Evgeniya
    Audette, Charlene
    Kovtun, Yelena
    Daver, Naval
    Wang, Sa A.
    Pierce, Sherry
    Konoplev, Sergej N.
    Khogeer, Haitham
    Jorgensen, Jeffrey L.
    Konopleva, Marina
    Zweidler-McKay, Patrick A.
    Medeiros, L. Jeffrey
    Kantarjian, Hagop M.
    Jabbour, Elias J.
    Khoury, Joseph D.
    HAEMATOLOGICA, 2019, 104 (04) : 749 - 755
  • [4] CD123 targeting oncolytic adenoviruses suppress acute myeloid leukemia cell proliferation in vitro and in vivo
    G Li
    X Li
    H Wu
    X Yang
    Y Zhang
    L Chen
    X Wu
    L Cui
    L Wu
    J Luo
    X Y Liu
    Blood Cancer Journal, 2014, 4 : e194 - e194
  • [5] Development of Highly Optimized Antibody-Drug Conjugates against CD33 and CD123 for Acute Myeloid Leukemia
    Han, Yoon-Chi
    Kahler, Jennifer
    Piche-Nicholas, Nicole
    Hu, Wenyue
    Thibault, Stephane
    Jiang, Fan
    Leal, Mauricio
    Katragadda, Madan
    Maderna, Andreas
    Dushin, Russell
    Prashad, Nadira
    Charati, Manoj B.
    Clark, Tracey
    Tumey, L. Nathan
    Tan, Xingzhi
    Giannakou, Andreas
    Rosfjord, Edward
    Gerber, Hans-Peter
    Tchistiakova, Lioudmila
    Loganzo, Frank
    O'Donnell, Christopher J.
    Sapra, Puja
    CLINICAL CANCER RESEARCH, 2021, 27 (02) : 622 - 631
  • [6] CD123 targeting oncolytic adenoviruses suppress acute myeloid leukemia cell proliferation in vitro and in vivo
    Li, G.
    Li, X.
    Wu, H.
    Yang, X.
    Zhang, Y.
    Chen, L.
    Wu, X.
    Cui, L.
    Wu, L.
    Luo, J.
    Liu, X. Y.
    BLOOD CANCER JOURNAL, 2014, 4 : e194 - e194
  • [7] Characterization of SGN-CD123A, APotent CD123-Directed Antibody-Drug Conjugate for Acute Myeloid Leukemia
    Li, Fu
    Sutherland, May Kung
    Yu, Changpu
    Walter, Roland B.
    Westendorf, Lori
    Valliere-Douglass, John
    Pan, Lucy
    Cronkite, Ashley
    Sussman, Django
    Klussman, Kerry
    Ulrich, Michelle
    Anderson, Martha E.
    Stone, Ivan J.
    Zeng, Weiping
    Jonas, Mechthild
    Lewis, Timothy S.
    Goswami, Maitrayee
    Wang, Sa A.
    Senter, Peter D.
    Law, Che-Leung
    Feldman, Eric J.
    Benjamin, Dennis R.
    MOLECULAR CANCER THERAPEUTICS, 2018, 17 (02) : 554 - 564
  • [8] A novel immunoliposome mediated by CD123 antibody targeting to acute myeloid leukemia cells
    Wang, Yin
    Liu, Furong
    Wang, Qiantao
    Xiang, Honglin
    Jin, Hui
    Li, Hui
    Mao, Shengjun
    INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2017, 529 (1-2) : 531 - 542
  • [9] Immunotherapeutic Targeting of Mesothelin in Acute Myeloid Leukemia in Vitro with Anetumab Ravtansine and a Novel Antibody-Drug Conjugate
    Kaeding, Allison
    Tarlock, Katherine
    Kolb, E. Anders
    Meshinchi, Soheil
    BLOOD, 2018, 132
  • [10] The CD123 antibody-drug conjugate pivekimab sunirine exerts profound activity in preclinical models of pediatric acute lymphoblastic leukemia
    Watts, Ben
    Smith, Christopher M.
    Evans, Kathryn
    Gifford, Andrew J.
    Mohamed, Sara M. A.
    Erickson, Stephen W.
    Earley, Eric J.
    Neuhauser, Steven
    Stearns, Timothy M.
    Philip, Vivek M.
    Chuang, Jeffrey H.
    Zweidler-McKay, Patrick A.
    Lakshmikanthan, Sribalaji
    Jocoy, Emily L.
    Bult, Carol J.
    Teicher, Beverly A.
    Smith, Malcolm A.
    Lock, Richard B.
    HEMASPHERE, 2025, 9 (01):