Effects of dexmedetomidine in non-operating room anesthesia in adults: a systematic review with meta-analysis

被引:4
|
作者
Fonseca, Francisca Jeronimo [1 ]
Ferreira, Leonardo [2 ]
Rouxinol-Dias, Ana Lidia [2 ,3 ,4 ]
Mourao, Joana [1 ,2 ]
机构
[1] Fac Med Univ Porto, Fac Med, Porto, Portugal
[2] Sao Joao Univ Hosp Ctr, Dept Anesthesiol, Porto, Portugal
[3] Univ Porto, Fac Med, MEDCIDS, Dept Community Med Informat & Decis Hlth, Porto, Portugal
[4] Univ Porto, Ctr Hlth Technol & Serv Res, Fac Med, CINTESIS, Porto, Portugal
来源
BRAZILIAN JOURNAL OF ANESTHESIOLOGY | 2023年 / 73卷 / 05期
关键词
Anesthesiology; Conscious sedation; Dexmedetomidine; Hypnotics and sedatives; Patient safety; ENDOSCOPIC RETROGRADE CHOLANGIOPANCREATOGRAPHY; LOW-DOSE DEXMEDETOMIDINE; INDUCED SLEEP ENDOSCOPY; 3 SEDATION REGIMENS; 3RD MOLAR SURGERY; CONSCIOUS SEDATION; DOUBLE-BLIND; FLEXIBLE BRONCHOSCOPY; PROCEDURAL SEDATION; INTRANASAL DEXMEDETOMIDINE;
D O I
10.1016/j.bjane.2021.12.002
中图分类号
R614 [麻醉学];
学科分类号
100217 ;
摘要
Background: Dexmedetomidine (DEX) is an a2-adrenergic receptor agonist used for its sedative, analgesic, and anxiolytic effects. Non-Operating Room Anesthesia (NORA) is a modality of anes-thesia that can be done under general anesthesia or procedural sedation or/and analgesia. In this particular setting, a level-2 sedation, such as the one provided by DEX, is beneficial. We aimed to study the effects and safety of DEX in the different NORA settings in the adult population.Methods: A systematic review with meta-analysis of randomized controlled trials was con-ducted. Interventions using DEX only or DEX associated with other sedative agents, in adults (18 years old or more), were included. Procedures outside the NORA setting and/or without a control group without DEX were excluded. MEDLINE, ClinicalTrials.gov, Scopus, LILACS, and SciELO were searched. The primary outcome was time until full recovery. Secondary outcomes included hemodynamic and respiratory complications and other adverse events, among others.Results: A total of 97 studies were included with a total of 6,706 participants. The meta-analysis demonstrated that DEX had a higher time until full recovery (95% CI = [0.34, 3.13] minutes, a higher incidence of hypotension (OR = 1.95 [1.25, 3.05], p = 0.003, I2 = 39%) and bradycardia (OR = 3.60 [2.29, 5.67], p < 0.00001, I2 = 0%), and a lower incidence of desaturation (OR = 0.40 [0.25, 0.66], p = 0.0003, I2 = 60%).Conclusion: DEX in NORA procedures in adults was associated with a lower incidence of amnesia and respiratory effects but had a long time to recovery and more hemodynamic complications. (c) 2021 Sociedade Brasileira de Anestesiologia. Published by Elsevier Editora Ltda. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/ 4.0/).
引用
收藏
页码:641 / 664
页数:24
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