E3 ubiquitin ligases and deubiquitinases in bladder cancer tumorigenesis and implications for immunotherapies

被引:8
|
作者
Wang, Maoyu [1 ]
Zhang, Zhensheng [1 ]
Li, Zhizhou [1 ]
Zhu, Yasheng [1 ,2 ]
Xu, Chuanliang [1 ]
机构
[1] Naval Med Univ, Shanghai Changhai Hosp, Dept Urol, Shanghai, Peoples R China
[2] Naval Med Univ, Shanghai Changzheng Hosp, Dept Urol, Shanghai, Peoples R China
来源
FRONTIERS IN IMMUNOLOGY | 2023年 / 14卷
关键词
bladder cancer; E3 ubiquitin ligase; deubiquitinases; immunotherapy; tumorigenesis; NF-KAPPA-B; DOWN-REGULATE PD-L1; GENOTOXIC STRESS; IMMUNE-RESPONSE; DNA-PKCS; EXPRESSION; RNF126; PROGRESSION; GROWTH; CELLS;
D O I
10.3389/fimmu.2023.1226057
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
With the rapidly increasing incidence of bladder cancer in China and worldwide, great efforts have been made to understand the detailed mechanism of bladder cancer tumorigenesis. Recently, the introduction of immune checkpoint inhibitor-based immunotherapy has changed the treatment strategy for bladder cancer, especially for advanced bladder cancer, and has improved the survival of patients. The ubiquitin-proteasome system, which affects many biological processes, plays an important role in bladder cancer. Several E3 ubiquitin ligases and deubiquitinases target immune checkpoints, either directly or indirectly. In this review, we summarize the recent progress in E3 ubiquitin ligases and deubiquitinases in bladder cancer tumorigenesis and further highlight the implications for bladder cancer immunotherapies.
引用
收藏
页数:12
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