Mutant p53 Gain-of-Function in the Spotlight: Are We Suffering a GOF Delusion?

被引：1

作者：

Lane, David P. ^{[1
,2
]}

机构：

[1] Karolinska Inst, Dept Microbiol Tumor & Cell Biol, Solna, Sweden

[2] Karolinska Inst, Dept Microbiol Tumor & Cell Biol, Solnavagen 9, S-17165 Solna, Sweden

来源：

CANCER DISCOVERY | 2024年 / 14卷 / 02期

关键词：

TP53; GENE;

D O I：

10.1158/2159-8290.CD-23-1362

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Mutant p53 proteins are often highly expressed in human cancers and have been thought to have oncogenic driver gain-of-function (GOF) properties. Wang and colleagues show, surprisingly, that this is not the case because removing the TP53-mutant gene from human and mouse cancer cells using CRISPR technology has no effect on cancer cell growth in vitro or in vivo.

引用

页码：211 / 213

页数：3

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