Vision-Related Quality of Life Among Healthy, Preperimetric Glaucoma, and Perimetric

center dot PURPOSE: To investigate the association of visionrelated quality of life (VRQOL) with the central visual field and macular ganglion cell complex (GCC) thickness in healthy control participants, patients with preperimetric glaucoma, and patients with perimetric glaucoma. center dot DESIGN: Retrospective cross-sectional study. center dot METHODS: A total of 39 healthy, 34 preperimetric glaucoma, and 145 perimetric glaucoma patients comtion Questionnaire (NEI-VFQ). A linear mixed-effect models was used to investigate the association between the glaucoma stage as measured by binocular 10-2 visual field mean sensitivity (VFMS) and GCC thickness with the Rasch-calibrated NEI-VFQ score. center dot RESULTS: A total of 436 eyes from 218 participants (mean age = 67.2 [95% CI = 65.1 to 69.2] years) were enrolled. VRQOL calculated by the NEI-VFQ Raschcalibrated score was worst for patients with perimetric glaucoma (50.7 [95% CI = 47.2 to 54.2]), followed by patients with preperimetric glaucoma (41.2 [95% CI = 34.5 to 47.9]) and healthy controls (29.3 [95% CI = 24.0 to 34.7]. Worse VRQOL had a moderate association with a worse global binocular 10-2 VFMS ( -3.4 [95% CI = -5.0 to -1.9] dB per 1 score; P < .001; adjusted R 2 = 0.27), but not with a thinner global GCC in the better eye ( -0.1 [95% CI = -0.2 to 0.1] mu m per 1 score; P = .0485; adjusted R 2 = 0.17). center dot CONCLUSIONS: These findings suggest that patients with perimetric and preperimetric glaucoma have worse VRQOL than patients with healthy eyes. As compared to macular thickness measurements, the central visual field is more strongly associated with VRQOL and may better help to identify patients in need of intervention. (Am J Ophthalmol 2023;248: 127-136. (c) 2022 Elsevier Inc. All rights reserved.)