Local treatment of liver metastasis in a patient with advanced malignant melanoma: A case report

被引:1
|
作者
Hong, Hongxi [1 ]
Shen, Lujun [2 ,3 ]
Tan, Hongtong [2 ,3 ]
Wu, Ying [2 ,3 ]
Liu, Ying [2 ,3 ]
Fan, Weijun [2 ,3 ,4 ]
机构
[1] Hosp Tradit Chinese Med Guangdong Prov, Dept Oncol, Guangzhou, Peoples R China
[2] Sun Yat Sen Univ, Dept Minimally Invas Intervent Therapy, Canc Ctr, Guangzhou, Peoples R China
[3] Sun Yat Sen Univ, Collaborat Innovat Ctr Canc Med, State Key Lab Oncol South China, Guangzhou, Peoples R China
[4] Sun Yat Sen Univ, Canc Ctr, Dept Med Imaging & Intervent Radiol, 651 Dongfeng East Rd, Guangzhou 510060, Peoples R China
关键词
Cryoablation; immunotherapy; liver metastasis; melanoma; toripalimab; EFFICACY; THERAPY; PEMBROLIZUMAB; CRYOABLATION; COMBINATION; IPILIMUMAB; SAFETY;
D O I
10.4103/jcrt.jcrt_394_22
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Melanoma is a fatal malignant tumor with a high rate of metastasis. Liver metastasis of melanoma is always associated with insensitivity to immunotherapy and a poor prognosis. However, the combination of cryoablation, which is believed to stimulate the antitumor immune response in the body, with immunotherapy can improve the therapeutic response to this condition. Herein, we present the case of a 79-year-old woman with BRAF (B-Raf proto-oncogene) wild-type melanoma who later developed liver metastasis. The patient received intravenous antiprogrammed cell death 1 antibody, which showed poor efficacy, and subsequent treatment with immunotherapy combined with cryoablation yielded a partial response. However, after the second cryoablation, the patient refused further treatment due to a fear of bleeding. Therefore, only immunotherapy was provided, which resulted in disease progression. This report demonstrates the need to consider immunotherapy plus cryoablation for the treatment of liver metastases in patients with BRAF wild-type melanoma.
引用
收藏
页码:1675 / 1679
页数:5
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