DEVELOPMENT OF A FUNCTIONAL PLATFORM FOR REAL-TIME PERSONALIZED DRUG SENSITIVITY PROFILING OF PATIENT-DERIVED 3D FRESH TUMOR TISSUE CULTURES IN THE PEDIATRIC PRECISION ONCOLOGY PROGRAM INFORM

被引：0

作者：

Peterziel, Heike ^{[1
,2
,3
]}

Jamaladdin, Nora ^{[1
,2
,3
]}

El Harouni, Dina ^{[1
,3
,4
]}

Gerloff, Xenia F. ^{[1
,2
]}

Herter, Sonja ^{[1
,2
,3
]}

Fiesel, Petra ^{[1
,5
]}

Berker, Yannick ^{[1
,2
,3
]}

Blattner-Johnson, Mirjam ^{[1
,3
,6
]}

Schramm, Kathrin ^{[1
,3
,6
]}

Jones, Barbara C. ^{[1
,3
,7
]}

Reuss, David ^{[8
]}

Turunen, Laura ^{[9
]}

Friedenauer, Aileen ^{[1
,2
,3
]}

Holland-Letz, Tim ^{[10
]}

Sill, Martin ^{[1
,11
]}

Weiser, Lena ^{[12
]}

Previti, Christopher ^{[3
,4
]}

Ubramanian, Gnanaprakash Balas ^{[1
,11
]}

Gerber, Nicolas U. ^{[13
]}

Gojo, Johannes ^{[14
,15
]}

Hutter, Caroline ^{[16
,17
]}

Ora, Ingrid ^{[18
]}

Lohi, Olli ^{[19
,20
]}

Kattamis, Antonis ^{[21
]}

De Wilde, Bram ^{[22
]}

Termann, Frank Wes ^{[1
,23
]}

Tippelt, Stephan ^{[24
]}

Graf, Norbert ^{[25
]}

Nathrath, Michaela ^{[26
,27
,28
]}

Sparber-Sauer, Monika ^{[29
,30
]}

Sehested, Astrid ^{[31
]}

Kramm, Christof M. ^{[32
]}

Dirksen, Uta ^{[33
]}

Kallioniemi, Olli ^{[34
]}

Pfister, Stefan M. ^{[1
,35
,36
]}

Van Tilburg, Cornelis M. ^{[1
,36
,37
]}

Jones, David T. W. ^{[1
,6
]}

Saarela, Jani

Pietiainen, Vilja

Jager, Natalie ^{[1
,11
]}

Schlesner, Matthias ^{[38
,39
,40
]}

Kopp-Schneider, Annette ^{[41
]}

Oppermann, Sina ^{[1
,2
,3
]}

Milde, Till ^{[1
,37
]}

Witt, Olaf ^{[1
,37
]}

Oehme, Ina ^{[1
,2
,3
]}

机构：

[1] Hopp Childrens Canc Ctr Heidelberg KiTZ, Heidelberg, Germany

[2] German Canc Res Ctr, Natl Ctr Tumor Dis NCT Heidelberg, Clin Cooperat Unit Pediat Oncol, Heidelberg, Germany

[3] German Canc Consortium DKTK, Heidelberg, Germany

[4] German Canc Res Ctr, Div Pediat Neurooncol, Bioinformat & Omics Data Analyt, Heidelberg, Germany

[5] German Canc Res Ctr, Clin Cooperat Unit Neuropathol, Heidelberg, Germany

[6] German Canc Res Ctr, Div Pediat Glioma Res, Heidelberg, Germany

[7] Univ Heidelberg Hosp, Div Pediat Glioma Res, Dept Pediat Oncol, German Canc Res Ctr DKFZ, Heidelberg, Germany

[8] Univ Heidelberg Hosp, Dept Neuropathol, Inst Pathol, Heidelberg, Germany

[9] Univ Helsinki, Inst Mol Med Finland FIMM, Helsinki Inst Life Sci HiLIFE, Helsinki, Finland

[10] German Canc Res Ctr, Div Biostatist, Heidelberg, Germany

[11] German Canc Res Ctr DKFZ Heidelberg, Div Pediat Neurooncol, Heidelberg, Germany

[12] German Canc Res Ctr, Core Facil Omics IT & Data Management ODCF, Heidelberg, Germany

[13] Univ Childrens Hosp Zurich, Dept Oncol, Zurich, Switzerland

[14] Med Univ Vienna, Dept Pediat & Adolescent Med, Comprehens Canc Ctr, Vienna, Austria

[15] Med Univ Vienna, Comprehens Ctr Pediat, Vienna, Austria

[16] Med Univ Vienna, St Anna Childrens Hosp, Dept Pediat & Adolescent Med, Vienna, Austria

[17] St Anna Childrens Canc Res Inst CCRI, Vienna, Austria

[18] Lund & Karolinska Univ Hosp, Skane Univ Hosp, Childrens Hosp, Pediat Oncol, Stockholm, Sweden

[19] Tampere Univ, Tampere Ctr Child Hlth Res, Fac Med & Hlth Technol, Tampere, Finland

[20] Tampere Univ Hosp, Tays Canc Ctr, Tampere, Finland

[21] Natl & Kapodistrian Univ Athens, Dept Pediat 1, Athens, Greece

[22] Univ Ghent, Ctr Med Genet, Ghent, Belgium

[23] German Canc Res Ctr, Div Neuroblastoma Genom, Heidelberg, Germany

[24] Univ Hosp Essen, Pediatr 3, Pediat Oncol & Hematol, Essen, Germany

[25] Saarland Univ, Dept Pediat Oncol, Med Ctr, Homburg, Germany

[26] Klinikum Kassel, Dept Pediat Oncol, Kassel, Germany

[27] Tech Univ Munich, Dept Pediat, Munich, Germany

[28] Tech Univ Munich, Childrens Canc Res Ctr, Klinikum Rechts Isar, Munich, Germany

[29] Klinikum Landeshauptstadt Stuttgart gKAoR, Stuttgart Canc Ctr, Olgahosp, Zentrum Kinder,Jugend & Frauenmed,Padiat Padiat O, Stuttgart, Germany

[30] Univ Med Tubingen, Tubingen, Germany

[31] Rigshosp, Dept Pediat & Adolescent Med, Copenhagen, Denmark

[32] Univ Med Ctr Gottingen, Div Pediat Hematol & Oncol, Gottingen, Germany

[33] Univ Hosp Essen, West German Canc Ctr, Pediat Pediat Hematol,Oncol Immunol Cardiol Pulmo, Essen, Germany

[34] Univ Helsinki, iCAN Digital Precis Canc Med Flagship, Helsinki, Finland

[35] Univ Heidelberg Hosp, Div Pediat Neurooncol, German Canc Res Ctr DKFZ, Heidelberg, Germany

[36] Univ Heidelberg Hosp, Dept Pediat Oncol Hematol Immunol & Pulmonol, German Canc Consortium DKTK, Heidelberg, Germany

[37] German Canc Res Ctr, Clin Cooperat Unit Pediat Oncol, Natl Ctr Tumor Dis NCT Heidelberg, Heidelberg, Germany

[38] German Canc Res Ctr, Bioinformat & Omics Data Analyt, Heidelberg, Germany

[39] Univ Augsburg, Fac Appl Comp Sci, Biomed Informat Data Min & Data Analyt, Augsburg, Germany

[40] Univ Augsburg, Fac Med, Augsburg, Germany

[41] German Canc Res Ctr, Div Biostat, Heidelberg, Germany

来源：

NEURO-ONCOLOGY | 2023年 / 25卷

关键词：

D O I：

10.1093/neuonc/noad073.286

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

OTHR-04

引用

页数：2

共 9 条

[1] Drug sensitivity profiling of 3D tumor tissue cultures in the pediatric precision oncology program INFORM
Peterziel, Heike
Jamaladdin, Nora
ElHarouni, Dina
Gerloff, Xenia F.
Herter, Sonja
Fiesel, Petra
Berker, Yannick
Blattner-Johnson, Mirjam
Schramm, Kathrin
Jones, Barbara C.
Reuss, David
Turunen, Laura
Friedenauer, Aileen
Holland-Letz, Tim
Sill, Martin
Weiser, Lena
Previti, Christopher
Balasubramanian, Gnanaprakash
Gerber, Nicolas U.
Gojo, Johannes
Hutter, Caroline
Ora, Ingrid
Lohi, Olli
Kattamis, Antonis
de Wilde, Bram
Westermann, Frank
Tippelt, Stephan
Graf, Norbert
Nathrath, Michaela
Sparber-Sauer, Monika
Sehested, Astrid
Kramm, Christof M.
Dirksen, Uta
Kallioniemi, Olli
Pfister, Stefan M.
van Tilburg, Cornelis M.
Jones, David T. W.
Saarela, Jani
Pietiaeinen, Vilja
Jaeger, Natalie
Schlesner, Matthias
Kopp-Schneider, Annette
Oppermann, Sina
Milde, Till
Witt, Olaf
Oehme, Ina
[J]. NPJ PRECISION ONCOLOGY, 2022, 6 (01)
[2] Drug sensitivity profiling of 3D tumor tissue cultures in the pediatric precision oncology program INFORM
Heike Peterziel
Nora Jamaladdin
Dina ElHarouni
Xenia F. Gerloff
Sonja Herter
Petra Fiesel
Yannick Berker
Mirjam Blattner-Johnson
Kathrin Schramm
Barbara C. Jones
David Reuss
Laura Turunen
Aileen Friedenauer
Tim Holland-Letz
Martin Sill
Lena Weiser
Christopher Previti
Gnanaprakash Balasubramanian
Nicolas U. Gerber
Johannes Gojo
Caroline Hutter
Ingrid Øra
Olli Lohi
Antonis Kattamis
Bram de Wilde
Frank Westermann
Stephan Tippelt
Norbert Graf
Michaela Nathrath
Monika Sparber-Sauer
Astrid Sehested
Christof M. Kramm
Uta Dirksen
Olli Kallioniemi
Stefan M. Pfister
Cornelis M. van Tilburg
David T. W. Jones
Jani Saarela
Vilja Pietiäinen
Natalie Jäger
Matthias Schlesner
Annette Kopp-Schneider
Sina Oppermann
Till Milde
Olaf Witt
Ina Oehme
[J]. npj Precision Oncology, 6
[3] Patient-derived 3D tumor cultures for clinical diagnostics and pre-clinical drug development
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[J]. CANCER RESEARCH, 2018, 78 (13)
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[5] A novel 3D ex vivo platform of fresh patient tumor tissue with intact tumor microenvironment for immuno-oncology drug development and biomarker discovery
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[J]. JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2017, 5
[6] Development of Patient-Derived 3D Tumor Organoids Combined with Immune Cells, as Preclinical Testing Platform for Personalized Cancer Immunotherapy
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[J]. MOLECULAR THERAPY, 2023, 31 (04) : 658 - 659
[7] Development of a Patient-Derived 3D Immuno-Oncology Platform to Potentiate Immunotherapy Responses in Ascites-Derived Circulating Tumor Cells
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Green, Allen
Campisi, Marco
Chen, Minyue
Gjeci, Iliana
Mahadevan, Navin
Lee, Catherine A. A.
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[J]. CANCERS, 2023, 15 (16)
[8] Novel patient avatar platform for oncology drug testing using 3D ex vivo models derived from fresh patient tumor tissues
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Price, Leo
[J]. MOLECULAR CANCER THERAPEUTICS, 2021, 20 (12)
[9] Leveraging artificial intelligence to advance immuno-oncology drug development using functional ex-vivo 3D-tumor organoid platforms of fresh patient tissue samples
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