Frequency of ischaemic stroke and intracranial haemorrhage in patients with reversible cerebral vasoconstriction syndrome (RCVS) and posterior reversible encephalopathy syndrome (PRES) - A systematic review

被引:5
|
作者
Kaufmann, Jana [1 ,2 ]
Buecke, Philipp [1 ,2 ]
Meinel, Thomas [1 ,2 ]
Beyeler, Morin [1 ,2 ]
Scutelnic, Adrian [1 ,2 ]
Kaesmacher, Johannes [2 ,3 ]
Mujanovic, Adnan [2 ,3 ]
Dobrocky, Thomas [2 ,3 ]
Arsany, Hakim [2 ,3 ]
Peters, Nils [4 ,5 ]
Z'Graggen, Werner [1 ,2 ,6 ]
Jung, Simon [1 ,2 ]
Seiffge, David [1 ,2 ,7 ]
机构
[1] Inselspital Univ Hosp, Dept Neurol, Bern, Switzerland
[2] Univ Bern, Bern, Switzerland
[3] Inselspital Univ Hosp, Inst Diagnost & Intervent Neuroradiol, Bern, Switzerland
[4] Univ Basel, Univ Dept Geriatr Med Felix Platter, Neurol & Neurorehabil, Basel, Switzerland
[5] Hirslanden Clin, Stroke Ctr, Zurich, Switzerland
[6] Inselspital Univ Hosp, Dept Neurosurg, Bern, Switzerland
[7] Univ Bern, Dept Neurol, Inselspital Univ Hosp Bern, Freiburgstr 18, CH-3010 Bern, Switzerland
关键词
intracranial haemorrhage; ischaemic stroke; posterior reversible encephalopathy syndrome; PRES; RCVS; reversible cerebral vasoconstriction syndrome; RADIOLOGICAL SPECTRUM; MR PERFUSION; RISK-FACTORS; MANIFESTATIONS; ANGIOGRAPHY; PREDICTORS; DIAGNOSIS; FEATURES; OUTCOMES; UTILITY;
D O I
10.1111/ene.16246
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background: Posterior reversible encephalopathy syndrome (PRES) and reversible cerebral vasoconstriction syndrome (RCVS) may cause ischaemic stroke and intracranial haemorrhage. The aim of our study was to assess the frequency of the afore-mentioned outcomes. Methods: We performed a PROSPERO-registered (CRD42022355704) systematic review and meta-analysis accessing PubMed until 7 November 2022. The inclusion criteria were: (1) original publication, (2) adult patients (>= 18 years), (3) enrolling patients with PRES and/or RCVS, (4) English language and (5) outcome information. Outcomes were frequency of (1) ischaemic stroke and (2) intracranial haemorrhage, divided into subarachnoid haemorrhage (SAH) and intraparenchymal haemorrhage (IPH). The Cochrane Risk of Bias tool was used. Results: We identified 848 studies and included 48 relevant studies after reviewing titles, abstracts and full text. We found 11 studies on RCVS (unselected patients), reporting on 2746 patients. Among the patients analysed, 15.9% (95% CI 9.6%-23.4%) had ischaemic stroke and 22.1% (95% CI 10%-39.6%) had intracranial haemorrhage. A further 20.3% (95% CI 11.2%-31.2%) had SAH and 6.7% (95% CI 3.6%-10.7%) had IPH. Furthermore, we found 28 studies on PRES (unselected patients), reporting on 1385 patients. Among the patients analysed, 11.2% (95% CI 7.9%-15%) had ischaemic stroke and 16.1% (95% CI 12.3%-20.3%) had intracranial haemorrhage. Further, 7% (95% CI 4.7%-9.9%) had SAH and 9.7% (95% CI 5.4%-15%) had IPH. Conclusions: Intracranial haemorrhage and ischaemic stroke are common outcomes in PRES and RCVS. The frequency reported in the individual studies varied considerably.
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页数:13
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