Thalassemia and malignancies: Updates from the literature

被引：1

作者：

Hodroj, Mohammad Hassan ^{[1
]}

Taher, Ali ^{[1
,2
]}

机构：

[1] Amer Univ Beirut, Med Ctr, Dept Internal Med, Div Hematol & Oncol, Beirut, Lebanon

[2] Amer Univ Beirut, Dept Internal Med, Div Hematol & Oncol, Med Ctr, Cairo St, Beirut 11072020, Lebanon

来源：

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES | 2023年 / 1529卷 / 01期

关键词：

malignancies; non-transfusion-dependent thalassemia; thalassemia; transfusion-dependent thalassemia; BETA-THALASSEMIA; HEPATOCELLULAR-CARCINOMA; HEMATOLOGICAL MALIGNANCIES; CELL-MIGRATION; IRON OVERLOAD; CANCER; INTERMEDIA; DISEASE; LEUKEMIA; PATIENT;

D O I：

10.1111/nyas.15061

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Thalassemia management has undergone significant development with the advancement in iron chelation therapy, which has led to a prolonged life expectancy. This has been accompanied by the emergence of several new morbidities and chronic diseases, including cancer. Over the years, multiple cases of solid and hematologic malignancies in thalassemia patients have been reported in the literature, with no clear mechanism for the development of cancer in these patients despite a number of potential mechanisms. However, the results of many studies have been contradictory regarding the risk of development of malignancies in thalassemia. The present review aims to discuss the available data on cancer and thalassemia in the literature, with the latest updates regarding possible malignancy development mechanisms, risks, and the most commonly reported types.

引用

页码：14 / 20

页数：7

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