This study analyses the economic effects of the sectoral lockdowns on the Western Mediterranean Region (TR61-Antalya, Isparta, Burdur) in Turkiye by employing the Hypothetical Extraction Method-HEM. The analyses used the year-2017 regional input-output table established for TR61. In addition, the study interprets the output and household income multipliers with the forward and backward linkage coefficients estimated by both the conventional approach and the HEM to find the impacts of lock-down and measures to recover. The study's findings point out that the sectoral lockdown created the most significant contraction in the region in tourism, transportation and logistics, agriculture, food industry and construction sectors. Moreover, the fishing sector is the sector most negatively affected by the lockdown of the tourism sector.