Sequential events during the quiescence to proliferation transition establish patterns of follicle cell differentiation in the Drosophila ovary

被引：0

作者：

Lee, Eric H. ^{[1
,2
]}

Zinshteyn, Daniel ^{[1
]}

Miglo, Fred ^{[1
,2
]}

Wang, Melissa Q. ^{[1
,2
]}

Reinach, Jessica ^{[2
]}

Chau, Cindy M. ^{[2
]}

Grosstephan, Joseph M. ^{[2
]}

Correa, Iliana ^{[2
]}

Costa, Kelly ^{[2
]}

Vargas, Alberto ^{[1
]}

Johnson, Aminah ^{[1
]}

Longo, Sheila M. ^{[1
,3
]}

Alexander, Jennifer I. ^{[1
,2
]}

O'Reilly, Alana M. ^{[1
,2
,3
]}

机构：

[1] Fox Chase Canc Ctr, Mol Therapeut Program, Philadelphia, PA 19111 USA

[2] Fox Chase Canc Ctr, Immers Sci Program, Philadelphia, PA 19111 USA

[3] Drexel Univ, Mol Biol & Genet Grad Program, Coll Med, Philadelphia, PA 19129 USA

来源：

BIOLOGY OPEN | 2023年 / 12卷 / 01期

关键词：

Stem cell; Self-renewal; Oogenesis; Quiescence to proliferation transition; Cytoplasmic projections; Cell fate; Follicle formation; ADULT STEM-CELLS; NEUTRAL COMPETITION; MOSAIC ANALYSIS; PROTEIN; NICHE; FATE; MAINTENANCE; HOMEOSTASIS; MECHANISMS; OOGENESIS;

D O I：

10.1242/bio.059625

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Stem cells cycle between periods of quiescence and proliferation to promote tissue health. In Drosophila ovaries, quiescence to proliferation transitions of follicle stem cells (FSCs) are exquisitely feeding-dependent. Here, we demonstrate feeding-dependent induction of follicle cell differentiation markers, eyes absent (Eya) and castor (Cas) in FSCs, a patterning process that does not depend on proliferation induction. Instead, FSCs extend micron-scale cytoplasmic projections that dictate Eya-Cas patterning. We identify still life and sickie as necessary and sufficient for FSC projection growth and Eya-Cas induction. Our results suggest that sequential, interdependent events establish long-term differentiation patterns in follicle cell precursors, independently of FSC proliferation induction.

引用

页数：14

共 37 条

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