A FLEXIBLE BIOSENSING PLATFORM FOR HIGH-THROUGHPUT MEASUREMENT OF CARDIOMYOCYTE CONTRACTILITY

被引：0
|
作者：
Dou, Wenkun [1 ]
Maynes, Jason [2 ]
Sun, Yu [1 ]
机构：
[1] Univ Toronto, Dept Mech & Ind Engn, Toronto, ON, Canada
[2] Hosp Sick Children, Program Mol Med, Toronto, ON, Canada
来源：
2023 IEEE 36TH INTERNATIONAL CONFERENCE ON MICRO ELECTRO MECHANICAL SYSTEMS, MEMS | 2023年
基金：
加拿大健康研究院;
关键词：
hiPSC-CMs; Microdevice array; Contractility; Drug testing; HEART-FAILURE; FORCE;
D O I：
10.1109/MEMS49605.2023.10052252
中图分类号：
TM [电工技术]; TN [电子技术、通信技术];
学科分类号：
0808 ; 0809 ;
摘要：
Contractile force generated by cardiomyocyte beatings is critical for pumping oxygenated blood supply from the heart to other organs. Measuring cardiomyocyte contractility is critical in exploring cardiac disease mechanisms and quantifying drug efficacy. This paper reports a novel biosensing platform that is integrated with an ultrathin membrane array, flexible carbon black (CB)-PDMS strain sensors, and carbon fiber electrodes for continuous and high-throughput measurement of contractility, beating rate, and beating rhythm in a monolayer of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs). The flexible biosensing array has been utilized to conduct high-throughput measurement of cardiomyocyte contractile function in responses to cardiac drug candidates.
引用
收藏
页码：29 / 32
页数：4
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