The effect of lipid metabolism on age-associated cognitive decline: Lessons learned from model organisms and human

被引：0
|
作者：
Wu, Shihao [1 ,2 ]
Liu, Xiaoli [3 ]
Yang, Haiyan [1 ,4 ]
Ma, Wenlin [2 ,5 ]
Qin, Zhao [1 ,4 ]
机构：
[1] Tongji Univ, Tongji Hosp, Sch Med, Key Lab Spine & Spinal Cord Injury Repair,Orthoped, Shanghai 200065, Peoples R China
[2] Tongji Univ, Tongji Hosp, Dept Geriatr Med, Sch Med, Shanghai 200065, Peoples R China
[3] Shanghai Jiao Tong Univ, Punan Branch, Renji Hosp, Sch Med, Shanghai 200125, Peoples R China
[4] Tongji Univ, Collaborat Innovat Ctr Brain Sci, Shanghai 200092, Peoples R China
[5] Shanghai Clin Res Ctr Aging & Med, Shanghai 200040, Peoples R China
来源：
IBRO NEUROSCIENCE REPORTS | 2023年 / 15卷
基金：
中国国家自然科学基金;
关键词：
Lipid metabolism; Age-associated cognitive decline; Model organisms; Human; CHOLESTEROL LEVELS; RISK-FACTORS; ALZHEIMERS-DISEASE; DEMENTIA; IMPAIRMENT; NEURODEGENERATION; DROSOPHILA; KNOCKOUT; DROPLETS; TRIGLYCERIDES;
D O I：
10.1016/j.ibneur.2023.08.2194
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Lipids are required as integral building blocks of cells to support cellular structures and functions. The intricate mechanisms underpinning lipid homeostasis are essential for the health and maintenance of the central nervous system. Here we summarize the recent advances in dissecting the effect of lipid metabolism on cognitive function and its age-associated decline by reviewing relevant studies ranging from invertebrate model organisms to mammals including human.
引用
收藏
页码：165 / 169
页数：5
相关论文
共 50 条
  • [1] Age-associated cognitive decline
    Deary, Ian J.
    Corley, Janie
    Gow, Alan J.
    Harris, Sarah E.
    Houlihan, Lorna M.
    Marioni, Riccardo E.
    Penke, Lars
    Rafnsson, Snorri B.
    Starr, John M.
    [J]. BRITISH MEDICAL BULLETIN, 2009, 92 (01) : 135 - 152
  • [2] Charting age-associated cognitive decline
    Costa, Andrew
    [J]. CANADIAN MEDICAL ASSOCIATION JOURNAL, 2017, 189 (48) : E1470 - E1471
  • [3] AUTOIMMUNITY AND AGE-ASSOCIATED COGNITIVE DECLINE
    LAL, H
    FORSTER, MJ
    [J]. NEUROBIOLOGY OF AGING, 1988, 9 (5-6) : 733 - 742
  • [4] Age-associated cognitive decline in healthy old people
    Starr, JM
    Deary, IJ
    Inch, S
    Cross, S
    MacLennan, IJ
    [J]. AGE AND AGEING, 1997, 26 (04) : 295 - 300
  • [5] Assessment of nutritional interventions for modification of age-associated cognitive decline using a canine model of human aging
    Joseph A. Araujo
    Christa M. Studzinski
    Elizabeth Head
    Carl W. Cotman
    Norton W. Milgram
    [J]. AGE, 2005, 27 : 27 - 37
  • [6] Assessment of nutritional interventions for modification of age-associated cognitive decline using a canine model of human aging
    Araujo, Joseph A.
    Studzinski, Christa M.
    Head, Elizabeth
    Cotman, Carl W.
    Milgram, Norton W.
    [J]. AGE, 2005, 27 (01) : 27 - 37
  • [7] Gait variability in older adults with age-associated cognitive decline
    Hausdorff, JM
    Mordechovitch, M
    Giladi, N
    [J]. NEUROLOGY, 2004, 62 (07) : A161 - A161
  • [8] Characterizing the therapeutic application of amphetamine in age-associated cognitive decline
    Scognamiglio, Serena
    Dezfuli, Ghazaul
    Kellar, Kenneth
    [J]. FASEB JOURNAL, 2021, 35
  • [9] Gait variability in older adults with age-associated cognitive decline
    Hausdorff, JM
    Mordechovitch, M
    Giladi, N
    [J]. MOVEMENT DISORDERS, 2004, 19 : S414 - S414
  • [10] The effect of micronutrients and fatty acids on age-associated cognitive decline in the elderly: a systematic review
    Jia, X.
    McNeill, G.
    Avenell, A.
    [J]. PROCEEDINGS OF THE NUTRITION SOCIETY, 2005, 64 : 32A - 32A
12345