High-throughput screening of mutations affecting SARS-CoV-2 spike functions

被引：4

作者：

Xia, Shuai ^{[1
]}

Liu, Zezhong ^{[1
]}

Jiang, Shibo ^{[1
]}

机构：

[1] Fudan Univ, Shanghai Inst Infect Dis & Biosecur, Chinese Acad Med Sci CAMS, Minist Educ MOE,Shanghai Med Coll,Natl Hlth Commis, Shanghai 200032, Peoples R China

来源：

TRENDS IN IMMUNOLOGY | 2023年 / 44卷 / 05期

基金：

中国国家自然科学基金;

关键词：

D O I：

10.1016/j.it.2023.03.010

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The spike (S) protein of SARS-CoV-2, which is undergoing rapid evolution, plays crucial roles in viral immune escape, infectivity, and transmissibility. To gain clinical insight, Dadonaite et al. developed a novel deep mutational scanning (DMS) platform for mapping the effects of S protein mutations on immune evasion and viral infectivity.

引用

页码：321 / 323

页数：3

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