The interaction between alpha-synuclein and mitochondrial dysfunction in Parkinson's disease

被引：4
|
作者：
Li, Hong-Yan [1 ]
Liu, De-Shui [2 ]
Zhang, Ying-Bo [2 ]
Rong, Hua [2 ]
Zhang, Xiao-Jie [1 ,3 ,4 ]
机构：
[1] Heilongjiang Univ Chinese Med, Dept Basic, Med Coll, Haerbin 150000, Peoples R China
[2] Qiqihar Med Univ, Dept Pathol, Qiqihar 161006, Peoples R China
[3] Heilongjiang Nursing Coll, Haerbin 150000, Peoples R China
[4] Heilongjiang Nursing Coll, Xuefu Rd 209, Haerbin 150000, Peoples R China
来源：
BIOPHYSICAL CHEMISTRY | 2023年 / 303卷
关键词：
Alpha-synuclein; Mitochondrial dysfunction; Parkinson's disease; Mitochondrial homeostasis; TRANSPORT; MODEL; CELL; DEGENERATION; AGGREGATION; TRAFFICKING; PGC-1-ALPHA; EXPRESSION; DOPAMINE; NEURONS;
D O I：
10.1016/j.bpc.2023.107122
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Parkinson's disease (PD) is an aging-associated neurodegenerative disorder with the hallmark of abnormal aggregates of alpha-synuclein (alpha-syn) in Lewy bodies (LBs) and Lewy neurites (LNs). Currently, pathogenic alpha-syn and mitochondrial dysfunction have been considered as prominent roles that give impetus to the PD onset. This review describes the alpha-syn pathology and mitochondrial alterations in PD, and focuses on how alpha-syn interacts with multiple aspects of mitochondrial homeostasis in the pathogenesis of PD.
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页数：9
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