Drug-Induced Liver Injury with Commonly Used Antibiotics in the All of Us Research Program
被引:5
|
作者:
Gu, Shaopeng
论文数: 0引用数: 0
h-index: 0
机构:
Univ South Dakota, Sanford Sch Med, Dept Internal Med, Sioux Falls, SD 57105 USA
Sanford Imagenet, Sioux Falls, SD 57105 USAUniv South Dakota, Sanford Sch Med, Dept Internal Med, Sioux Falls, SD 57105 USA
Gu, Shaopeng
[1
,2
]
Rajendiran, Govarthanan
论文数: 0引用数: 0
h-index: 0
机构:
Univ South Dakota, Sanford Sch Med, Dept Internal Med, Sioux Falls, SD 57105 USA
Sanford Med Ctr, Sect Gastroenterol Hepatol, Sioux Falls, SD USAUniv South Dakota, Sanford Sch Med, Dept Internal Med, Sioux Falls, SD 57105 USA
Rajendiran, Govarthanan
[1
,3
]
论文数: 引用数:
h-index:
机构:
Forest, Kennedy
[1
]
Tran, Tam C. C.
论文数: 0引用数: 0
h-index: 0
机构:Univ South Dakota, Sanford Sch Med, Dept Internal Med, Sioux Falls, SD 57105 USA
Tran, Tam C. C.
Denny, Joshua C. C.
论文数: 0引用数: 0
h-index: 0
机构:
Natl Human Genome Res Inst, Ctr Precis Hlth Res, NIH, Bethesda, MD USAUniv South Dakota, Sanford Sch Med, Dept Internal Med, Sioux Falls, SD 57105 USA
Denny, Joshua C. C.
[4
]
Larson, Eric A. A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ South Dakota, Sanford Sch Med, Dept Internal Med, Sioux Falls, SD 57105 USA
Sanford Imagenet, Sioux Falls, SD 57105 USAUniv South Dakota, Sanford Sch Med, Dept Internal Med, Sioux Falls, SD 57105 USA
Larson, Eric A. A.
[1
,2
]
Wilke, Russell A. A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ South Dakota, Sanford Sch Med, Dept Internal Med, Sioux Falls, SD 57105 USAUniv South Dakota, Sanford Sch Med, Dept Internal Med, Sioux Falls, SD 57105 USA
Wilke, Russell A. A.
[1
]
机构:
[1] Univ South Dakota, Sanford Sch Med, Dept Internal Med, Sioux Falls, SD 57105 USA
[2] Sanford Imagenet, Sioux Falls, SD 57105 USA
[3] Sanford Med Ctr, Sect Gastroenterol Hepatol, Sioux Falls, SD USA
[4] Natl Human Genome Res Inst, Ctr Precis Hlth Res, NIH, Bethesda, MD USA
Antibiotics are a known cause of idiosyncratic drug-induced liver injury (DILI). According to the Centers for Disease Control and Prevention, the five most commonly prescribed antibiotics in the United States are azithromycin, ciprofloxacin, cephalexin, amoxicillin, and amoxicillin-clavulanate. We quantified the frequency of acute DILI for these common antibiotics in the All of Us Research Program, one of the largest electronic health record (EHR)-linked research cohorts in the United States. Retrospective analyses were conducted applying a standardized phenotyping algorithm to de-identified clinical data available in the All of Us database for 318,598 study participants. Between February 1984 and December 2022, more than 30% of All of Us participants (n = 119,812 individuals) had been exposed to at least 1 of our 5 study drugs. Initial screening identified 591 potential case patients that met our preselected laboratory-based phenotyping criteria. Because DILI is a diagnosis of exclusion, we then used phenome scanning to narrow the case counts by (i) scanning all EHRs to identify all alternative diagnostic explanations for the laboratory abnormalities, and (ii) leveraging International Classification of Disease 9th revision (ICD)-9 and ICD 10th revision (ICD)-10 codes as exclusion criteria to eliminate misclassification. Our final case counts were 30 DILI cases with amoxicillin-clavulanate, 24 cases with azithromycin, 24 cases with ciprofloxacin, 22 cases with amoxicillin alone, and < 20 cases with cephalexin. These findings demonstrate that data from EHR-linked research cohorts can be efficiently mined to identify DILI cases related to the use of common antibiotics.
机构:Univ Louisville, Sch Med, Dept Med, Div Gastroenterol Hepatol, Louisville, KY 40292 USA
Pugh, Aaron J.
Barve, Ashutosh J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Louisville, Sch Med, Dept Med, Div Gastroenterol Hepatol, Louisville, KY 40292 USAUniv Louisville, Sch Med, Dept Med, Div Gastroenterol Hepatol, Louisville, KY 40292 USA
Barve, Ashutosh J.
论文数: 引用数:
h-index:
机构:
Falkner, Keith
Patel, Mihir
论文数: 0引用数: 0
h-index: 0
机构:Univ Louisville, Sch Med, Dept Med, Div Gastroenterol Hepatol, Louisville, KY 40292 USA
Patel, Mihir
McClain, Craig J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Louisville, Sch Med, Dept Med, Div Gastroenterol Hepatol, Louisville, KY 40292 USA
Univ Louisville, Sch Med, Dept Pharmacol & Toxicol, Louisville, KY 40292 USA
Louisville VAMC, Louisville, KY 40206 USAUniv Louisville, Sch Med, Dept Med, Div Gastroenterol Hepatol, Louisville, KY 40292 USA
机构:Adult Gerontology, Acute Care Nurse Practitioner Program, Louisiana Health Science Center – New Orleans, 1900 Gravier Street, Suite 156, New Orleans, 70112, LA