Determination of thiomersal and mercurial residues by photo-degradation and flow injection analysis with luminescence probing using carbon quantum dots prepared from thiourea

被引：4
|
作者：
Franco, Claudiomar R. [1 ]
Miranda-Andrades, Jarol R. [1 ]
Toloza, Carlos A. T. [2 ]
Larrude, Dunieskys G. [3 ]
Maqueira-Espinosa, Luis [1 ]
Aucelio, Ricardo Q. [1 ]
De Falco, Anna [1 ]
Pedrozo-Penafiel, Marlin J. [1 ]
机构：
[1] Pontificia Univ Catolica Rio De Janeiro PUC Rio, Chem Dept, Rio De Janeiro, RJ, Brazil
[2] Univ Costa, Dept Nat & Exact Sci, Barranquilla, Colombia
[3] Univ Prebiteriana Mackenzie, Engn Sch, Sao Paulo, Brazil
来源：
TALANTA OPEN | 2023年 / 7卷
关键词：
Mercury; Thiomersal; Vaccines; Flow injection analysis; Photo; -degradation; Carbon quantum dots; THIMEROSAL;
D O I：
10.1016/j.talo.2023.100184
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Thiomersal is an organomercurial compound but, despite that, it is widely used in vaccines formulations to inactivate organisms and toxins and to prevent microbial growth during storage and use. In this work, thiomersal (along with traces of mercurial residues) was determined after photo-degradation (using UV and H2O2) to produce Hg2+ that was determined by flow injection analysis using luminescence probing with carbon quantum dots (prepared from citric acid and thiourea). Linear analytical response was observed in the concentration range of 25 to 900 & mu;g L-1 and the method was efficiently applied to the determination of thiomersal in vaccines against hepatitis B and diphtheria-tetanus with recoveries ranging from 93 to 94%.
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页数：7
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