Sensitive Detection of Clenbuterol by Electrochemical Sensor Based on N-doped Cobalt Metal Organic Framework Modified Electrode

N-doped cobalt metal organic framework (N-Co-MOF) was synthesized by solvothermal method using trimesic acid as ligand and Co(2+)and polyvinyl pyrrolidone (PVP) as central metal ions and nitrogen source. The morphology and composition of the materials were characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), Fourier infrared spectroscopy (FT-IR) and X-ray photoelectron spectroscopy (XPS). The electrochemical sensor for detection of clenbuterol (CLB) was constructed on glassy carbon electrode (GCE) modified with N-Co-MOF. The cyclic voltammetry (CV) characterization results showed that the N-Co-MOF could provide more electrochemical active sites and significantly improve the electron transfer ability, and had good electrocatalytic oxidation activity for CLB. The linear range of the sensor for CLB was 0.01 similar to 29.5 mu mol/L, and the detection limit (3 sigma) was 4.6 nmol/L. The sensor had excellent anti-interference performance, good reproducibility and stability, and had good accuracy in detection of CLB in actual meat samples, recoveries of 98.5%-102.9%.