RNA structure determination: From 2D to 3D

被引：5

作者：

Deng, Jie ^{[1
]}

Fang, Xianyang ^{[2
,3
]}

Huang, Lin ^{[1
]}

Li, Shanshan ^{[4
,5
]}

Xu, Lilei ^{[2
]}

Ye, Keqiong ^{[3
,6
]}

Zhang, Jinsong ^{[7
,8
,9
]}

Zhang, Kaiming ^{[4
,5
]}

Zhang, Qiangfeng Cliff ^{[7
,8
,9
]}

机构：

[1] Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Guangdong Prov Key Lab Malignant Tumor Epigenet &, Guangdong Hong Kong Joint Lab RNA Med, Guangzhou 510120, Peoples R China

[2] Tsinghua Univ, Beijing Frontier Res Ctr Biol Struct, Ctr Synthet & Syst Biol, Sch Life Sci, Beijing 100084, Peoples R China

[3] Chinese Acad Sci, Inst Biophys, CAS Ctr Excellence Biomacromolecules, Key Lab RNA Biol, Beijing 100101, Peoples R China

[4] Univ Sci & Technol China, Div Life Sci & Med, MOE Key Lab Cellular Dynam, Hefei 230027, Peoples R China

[5] Univ Sci & Technol China, Ctr Adv Interdisciplinary Sci & Biomed IHM, Div Life Sci & Med, Hefei 230027, Peoples R China

[6] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

[7] Tsinghua Univ, Beijing Adv Innovat Ctr Struct Biol, Ctr Synthet & Syst Biol, Sch Life Sci,MOE Key Lab Bioinformat, Beijing 100084, Peoples R China

[8] Tsinghua Univ, Frontier Res Ctr Biol Struct, Ctr Synthet & Syst Biol, Sch Life Sci, Beijing 100084, Peoples R China

[9] Tsinghua Peking Ctr Life Sci, Beijing 100084, Peoples R China

来源：

FUNDAMENTAL RESEARCH | 2023年 / 3卷 / 05期

基金：

中国国家自然科学基金; 国家重点研发计划;

关键词：

RNA structure; RNA structure probing; X-ray crystallography; Nuclear magnetic resonance spectroscopy; Cryo-electron microscopy; Small angle X-ray scattering; X-RAY-SCATTERING; SECONDARY STRUCTURE DETERMINATION; PHENYLALANINE TRANSFER-RNA; CRYSTAL-STRUCTURE; LIGAND-BINDING; TOPOLOGICAL-STRUCTURE; NMR-SPECTROSCOPY; SHAPE-ANALYSIS; NONCODING RNA; REVEALS;

D O I：

10.1016/j.fmre.2023.06.001

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

RNA molecules serve a wide range of functions that are closely linked to their structures. The basic structural units of RNA consist of single-and double-stranded regions. In order to carry out advanced functions such as catalysis and ligand binding, certain types of RNAs can adopt higher-order structures. The analysis of RNA structures has progressed alongside advancements in structural biology techniques, but it comes with its own set of challenges and corresponding solutions. In this review, we will discuss recent advances in RNA structure analysis tech-niques, including structural probing methods, X-ray crystallography, nuclear magnetic resonance, cryo-electron microscopy, and small-angle X-ray scattering. Often, a combination of multiple techniques is employed for the in-tegrated analysis of RNA structures. We also survey important RNA structures that have been recently determined using various techniques.

引用

页码：727 / 737

页数：11

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