Recombinant Fowl aviadenovirus E (FAdV-E) penton base vaccination fails to confer protection against inclusion body hepatitis (IBH) in chickens

被引：3
|
作者：
De Luca, Carlotta [1 ,2 ,3 ]
Schachner, Anna [1 ]
Hess, Michael [1 ,2 ]
机构：
[1] Univ Vet Med, Christian Doppler Lab Innovat Poultry Vaccines IPO, Vienna, Austria
[2] Univ Vet Med, Dept Farm Anim & Vet Publ Hlth, Clin Poultry & Fish Med, Vienna, Austria
[3] Univ Vet Med, Clin Poultry & Fish Med, Veterinarpl 1, A-1210 Vienna, Austria
来源：
AVIAN PATHOLOGY | 2023年 / 52卷 / 04期
关键词：
Fowl adenovirus; FAdV-E; penton base; subunit vaccine; inclusion body hepatitis; humoral immunity; ADENOVIRUS; EFFICACY; PROTEINS; FIBER-2;
D O I：
10.1080/03079457.2023.2226085
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
Inclusion body hepatitis (IBH) is a metabolic disease affecting chickens, associated with different serotypes of fowl adenovirus (FAdV). Experimentally tested vaccines against IBH include several capsid-based subunit vaccines, but not the penton base protein. In the present study, specific pathogen-free chickens were vaccinated with recombinant penton base expressed from each of two different FAdV serotypes (FAdV-7 and FAdV-8b), followed by challenge with a virulent IBH-causing strain. No protection was observed with either vaccine, possibly due to the low immunogenicity of each protein and their inability to induce neutralizing antibodies in the host.
引用
收藏
页码：277 / 282
页数：6
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