Structure-activity Exploration of Positive Allosteric Modulators of the Mu-opioid Receptor

被引：0
|
作者：
Li, Mengchu [1 ]
Traynor, John [1 ]
Zhang, Sherrice [1 ]
Stanczyk, Matthew [1 ]
Gan, Xinmin [1 ]
White, Andrew [1 ]
机构：
[1] Univ Michigan, Ann Arbor, MI 48109 USA
来源：
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS | 2023年 / 385卷
关键词：
D O I：
10.1124/jpet.122.238420
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
565
引用
收藏
页数：1
相关论文
共 50 条
  • [1] Structure-Activity Relationships and Molecular Pharmacology of Positive Allosteric Modulators of the Mu-Opioid Receptor
    Li, Mengchu
    Gan, Xinmin
    Liu, Kun
    Walajapet, Rajeswaran
    Stanczyk, M. Alex
    Stewart, Hannah C.
    Rech, Jason C.
    White, Andrew D.
    Traynor, John R.
    ACS CHEMICAL NEUROSCIENCE, 2024, 16 (01): : 16 - 29
  • [2] Structure-Guided Discovery of Positive Allosteric Modulators of the Mu-Opioid Receptor
    Bisignano, Paola
    Burford, Neil T.
    Gerritz, Samuel W.
    Alt, Andrew
    Filizola, Marta
    BIOPHYSICAL JOURNAL, 2015, 108 (02) : 414A - 415A
  • [3] Analysis of Antinociception Produced by Positive Allosteric Modulators of the Mu-Opioid Receptor
    Kandasamy, Ram
    Traynor, John R.
    FASEB JOURNAL, 2018, 32 (01):
  • [4] REPLY TO ZHUANG ET AL.: Potential side effects of positive allosteric modulators of the mu-opioid receptor
    Traynor, John R.
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2021, 118 (28)
  • [5] A biased mu-opioid receptor positive allosteric modulator that does not alter receptor regulation
    Livingston, Kathryn E.
    Traynor, John R.
    FASEB JOURNAL, 2016, 30
  • [6] Discovery of positive allosteric modulators and silent allosteric modulators of the μ-opioid receptor
    Burford, Neil T.
    Clark, Mary J.
    Wehrman, Tom S.
    Gerritz, Samuel W.
    Banks, Martyn
    O'Connell, Jonathan
    Traynor, John R.
    Alt, Andrew
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (26) : 10830 - 10835
  • [7] Positive allosteric modulation of the mu-opioid receptor produces analgesia with reduced side effects
    Kandasamy, Ram
    Hillhouse, Todd M.
    Livingston, Kathryn E.
    Kochan, Kelsey E.
    Meurice, Claire
    Eans, Shainnel O.
    Li, Ming-Hua
    White, Andrew D.
    Roques, Bernard P.
    McLaughlin, Jay P.
    Ingram, Susan L.
    Burford, Neil T.
    Alt, Andrew
    Traynor, John R.
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2021, 118 (16)
  • [8] The first structure-activity relationship study of oxytocin as a positive allosteric modulator for the ? opioid receptor
    Mizuguchi, Takaaki
    Miyano, Kanako
    Yamauchi, Risa
    Yoshida, Yuki
    Takahashi, Hideki
    Yamazaki, Ami
    Ono, Haruka
    Inagaki, Miku
    Nonaka, Miki
    Uezono, Yasuhito
    Fujii, Hideaki
    PEPTIDES, 2023, 159
  • [9] Positive Allosteric Modulation of the Mu Opioid Receptor
    Kochan, Kelsey
    Traynor, John
    FASEB JOURNAL, 2022, 36
  • [10] Structure-Activity Relationship Study of Cannabidiol-Based Analogs as Negative Allosteric Modulators of the μ-Opioid Receptor
    Bosquez-Berger, Taryn
    Gudorf, Jessica A.
    Kuntz, Charles P.
    Desmond, Jacob A.
    Schlebach, Jonathan P.
    VanNieuwenhze, Michael S.
    Straiker, Alex
    JOURNAL OF MEDICINAL CHEMISTRY, 2023, 66 (14) : 9466 - 9494
12345