Anthrol reductases: discovery, role in biosynthesis and applications in natural product syntheses

被引:0
|
作者
Rajput, Anshul [1 ]
Manna, Tanaya [1 ]
Husain, Syed Masood [1 ]
机构
[1] SGPGIMS Campus, Ctr Biomed Res, Dept Biol & Synthet Chem, Raebareli Rd, Lucknow 226014, India
关键词
MELANIN BIOSYNTHESIS; MAGNAPORTHE-GRISEA; FUNGAL METABOLITES; ALOE-EMODIN; ANTHRAQUINONES; AFLATOXIN; PURIFICATION; CONVERSION; PATHWAY; MONODICTYPHENONE;
D O I
10.1039/d3np00027c
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Covering: up to 2023 Short-chain dehydrogenase/reductases (SDR) are known to catalyze the regio- and stereoselective reduction of a variety of substrate types. Investigations of the deoxygenation of emodin to chrysophanol has led to the discovery of the anthrol reductase activity of an SDR, MdpC involved in monodictyphenone biosynthesis of Aspergillus nidulans and provided access to (R)-dihydroanthracenone, a putative biosynthetic intermediate. This facilitated the identification of several MdpC-related enzymes involved in the biosynthesis of aflatoxins B1, cladofulvin, neosartorin, agnestins and bisanthraquinones. Because of their ability to catalyze the reduction of hydroanthraquinone (anthrols) using NADPH, they were named anthrol reductases. This review provides a comprehensive summary of all the anthrol reductases that have been identified and characterized in the last decade along with their role in the biosynthesis of natural products. In addition, the applications of these enzymes towards the chemoenzymatic synthesis of flavoskyrins, modified bisanthraquinones, 3-deoxy anthraquinones, chiral cycloketones and & beta;-halohydrins have been discussed.
引用
收藏
页码:1672 / 1686
页数:15
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