Advances in the Utilization of Zebrafish for Assessing and Understanding the Mechanisms of Nano-/Microparticles Toxicity in Water

被引:15
|
作者
Lei, Pengyu [1 ,2 ]
Zhang, Wenxia [2 ]
Ma, Jiahui [1 ,2 ]
Xia, Yuping [2 ]
Yu, Haiyang [1 ,2 ]
Du, Jiao [1 ,2 ]
Fang, Yimeng [1 ,2 ]
Wang, Lei [1 ,2 ]
Zhang, Kun [3 ]
Jin, Libo [1 ,2 ]
Sun, Da [1 ,2 ]
Zhong, Junbo [2 ]
机构
[1] Wenzhou Univ, Inst Life Sci, Wenzhou 325035, Peoples R China
[2] Wenzhou Univ, Biomed Collaborat Innovat Ctr Zhejiang Prov, Zigong 325035, Peoples R China
[3] Bioengn Coll Chongqing Univ, Key Lab Biorheol Sci, State & Local Joint Engn Lab Vasc Implants, Technol Minist Educ, Chongqing 400044, Peoples R China
关键词
zebrafish; nano-; microparticles; toxicity evaluation; toxicological mechanism; NERVOUS-SYSTEM; POLYSTYRENE NANOPARTICLES; DANIO-RERIO; NANOPLASTICS; EXPOSURE; MODEL; GUT; ACETYLCHOLINESTERASE; BIOACCUMULATION; MICROPLASTICS;
D O I
10.3390/toxics11040380
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
A large amount of nano-/microparticles (MNPs) are released into water, not only causing severe water pollution, but also negatively affecting organisms. Therefore, it is crucial to evaluate MNP toxicity and mechanisms in water. There is a significant degree of similarity between the genes, the central nervous system, the liver, the kidney, and the intestines of zebrafish and the human body. It has been shown that zebrafish are exceptionally suitable for evaluating the toxicity and action mechanisms of MNPs in water on reproduction, the central nervous system, and metabolism. Providing ideas and methods for studying MNP toxicity, this article discusses the toxicity and mechanisms of MNPs from zebrafish.
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页数:17
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