Metal-Free Catalyzed Oxidation/Decarboxylative [3+2] Cycloaddition Sequences of 3-Formylchromones to Access Pyrroles with Anti-Cancer Activity

被引：0

作者：

Li, Xue ^{[1
,2
]}

Chen, Xing-Yu ^{[1
]}

Fan, Bing-Ying ^{[1
]}

Yu, Qun ^{[1
]}

Lei, Jie ^{[1
,3
,4
]}

Xu, Zhi-Gang ^{[1
]}

Chen, Zhong-Zhu ^{[1
]}

机构：

[1] Chongqing Univ Arts & Sci, Coll Pharm, Natl & Local Joint Engn Res Ctr Targeted & Innovat, IATTI, Chongqing 402160, Peoples R China

[2] Chongqing Univ, Sch Pharmaceut Sci, Chongqing Key Lab Nat Prod Synth & Drug Res, Chongqing 400044, Peoples R China

[3] Southwest Univ, Sch Chem & Chem Engn, Inst Bioorgan Med Chem, Chongqing 400715, Peoples R China

[4] Chongqing Acad Chinese Mat Med, Chongqing 400067, Peoples R China

来源：

MOLECULES | 2023年 / 28卷 / 22期

关键词：

metal-free; decarboxylation; 3-formylchromones; pyrroles; anti-cancer activity; ONE-POT SYNTHESIS; SUBSTITUTED PYRROLES; DECARBOXYLATION; ISOCYANIDES; AGENTS; ACIDS;

D O I：

10.3390/molecules28227602

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

An efficient and direct approach to pyrroles was successfully developed by employing 3-formylchromones as decarboxylative coupling partners, and facilitated by microwave irradiation. The protocol utilizes easily accessible feedstocks, a catalytic amount of DBU without any metals, resulting in high efficiency and regioselectivity. Notably, all synthesized products were evaluated against five different cancer cell lines and compound 3l selectively inhibited the proliferation of HCT116 cells with an IC50 value of 10.65 mu M.

引用

页数：12

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