Distinct Co-occurring Morning and Evening Fatigue Profiles in Patients With Gastrointestinal Cancers Receiving Chemotherapy

被引:3
|
作者
Lin, Yufen [1 ]
Bailey, Donald E. [2 ]
Xiao, Canhua [1 ]
Hammer, Marilyn [3 ]
Paul, Steven M. [4 ]
Cooper, Bruce A. [4 ]
Conley, Yvette P. [5 ]
Levine, Jon D. [6 ]
Kober, Kord M. [4 ]
Miaskowski, Christine [4 ,6 ,7 ]
机构
[1] Emory Univ, Nell Hodgson Woodruff Sch Nursing, Atlanta, GA USA
[2] Duke Univ, Sch Nursing, Durham, NC USA
[3] Dana Farber Canc Inst, Boston, MA USA
[4] Univ Calif San Francisco, Sch Nursing, San Francisco, CA USA
[5] Univ Pittsburgh, Sch Nursing, Pittsburgh, PA USA
[6] Univ Calif San Francisco, Sch Med, San Francisco, CA USA
[7] Univ Calif San Francisco, Dept Physiol Nursing, 2 Koret Way,N631Y, San Francisco, CA 94143 USA
关键词
Chemotherapy; Cognitive dysfunction; Depression; Fatigue; Gastrointestinal cancer; Sleep disturbance; Stress; ONCOLOGY PATIENTS; SYMPTOM CLUSTER; SLEEP DISTURBANCES; SCALE; TRAJECTORIES; PREVALENCE; SEVERITY; IMPACT; DISTRESS; RATINGS;
D O I
10.1097/NCC.0000000000001148
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
BackgroundPatients with gastrointestinal cancers experience diurnal variations in fatigue severity during chemotherapy that decrease their functional status and quality of life.ObjectivesStudy purposes were to identify subgroups of patients with distinct co-occurring morning and evening fatigue profiles and evaluate for differences among these subgroups in demographic, clinical, stress, and symptom characteristics.MethodsPatients with gastrointestinal cancers (n = 405) completed questionnaires 6 times over 2 cycles of chemotherapy. The Lee Fatigue Scale was used to evaluate diurnal variations in fatigue severity. Latent profile analysis was used to identify subgroups of patients with distinct co-occurring morning AND evening fatigue profiles. Differences among the subgroups in demographic, clinical, stress, and symptom characteristics at enrollment were evaluated using parametric and nonparametric analyses.ResultsTwo classes were identified, namely: low morning and moderate evening fatigue (ie, Low-Moderate, 60.0%) and high morning and high evening fatigue (ie, Both High, 40.0%). Compared with the Low-Moderate class, the Both High class was significantly younger, female, unmarried, and unemployed and lacked regular exercise. In addition, they had childcare responsibilities, lower annual income, lower functional status, higher comorbidity burden, and self-reported anemia and depression. Patients in the Both High class reported higher levels of anxiety, depressive symptoms, sleep disturbance, pain, and stress, and lower levels of energy and cognitive function.ConclusionsFindings provide new insights into the risk factors for higher levels of co-occurring morning and evening fatigue in patients with gastrointestinal cancers.Implications for PracticeClinicians can use this information to identify high-risk patients and develop personalized symptom management interventions.
引用
收藏
页码:E28 / E37
页数:10
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