TRANSIENT CD19 MASKING WITH TAFASITAMAB DIMINISHES CART19 APOPTOSIS AND TUMOR PYROPTOSIS, RESULTING IN INCREASED THERAPEUTIC INDEX OF CART19 THERAPY IN PRECLINICAL MODELS

被引：0

作者：

Sakemura, Reona ^{[1
]}

Roman, Claudia Manriquez ^{[1
]}

Ilieva, Kristina ^{[2
]}

Augsberger, Christian ^{[2
]}

Patra-Kneuer, Maria ^{[2
]}

Heitmueller, Christina ^{[2
]}

Steidl, Stefan ^{[2
]}

Siegler, Elizabeth ^{[1
]}

Kenderian, Saad ^{[1
]}

机构：

[1] Mayo Clin, Rochester, MN USA

[2] MorphoSys AG, Planegg, Germany

来源：

BONE MARROW TRANSPLANTATION | 2023年 / 58卷 / SUPP1期

关键词：

D O I：

暂无

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

O109

引用

下载

页码：98 / 99

页数：2

共 11 条

[1] CD19 occupancy with tafasitamab increases therapeutic index of CART19 cell therapy and diminishes severity of CRS
Sakemura, R. Leo
Roman, Claudia Manriquez
Horvei, Paulina
Siegler, Elizabeth L.
Girsch, James H.
Sirpilla, Olivia L.
Stewart, Carli M.
Yun, Kun
Can, Ismail
Ogbodo, Ekene J.
Adada, Mohamad M.
Bezerra, Evandro D.
Fonkoua, Lionel Aurelien Kankeu
Hefazi, Mehrdad
Ruff, Michael W.
Kimball, Brooke L.
Mai, Long K.
Huynh, Truc N.
Nevala, Wendy K.
Ilieva, Kristina
Augsberger, Christian
Patra-Kneuer, Maria
Schanzer, Juergen
Endell, Jan
Heitmueller, Christina
Steidl, Stefan
Parikh, Sameer A.
Ding, Wei
Kay, Neil E.
Nowakowski, Grzegorz S.
Kenderian, Saad S.
BLOOD, 2024, 143 (03) : 258 - 271
[2] Affinity of Anti-CD19 Antibodies Determines Subsequent CART19 Activation, Apoptosis and CRS in Preclinical Models
Sakemura, R. Leo
Roman, Claudia Manriquez
Mai, Long K.
Kimball, Brooke L.
Truc Huynh
Feigin, Jennifer M.
Girsch, James H.
Sirpilla, Olivia L.
Yun, Kun
Stewart, Carli M.
Ruiz, Omar Gutierrez
Can, Ismail
Ogbodo, Ekene
Fonkoua, Lionel Aurelien Kankeu
Hefazi, Mehrdad
Ruff, Michael W.
Jaehrling, Jan
Ilieva, Kristina
Patra-Kneuer, Maria
Heitmueller, Christina
Steidl, Stefan
Siegler, Elizabeth L.
Kenderian, Saad S.
BLOOD, 2023, 142
[3] CD19 Antigen Occupancy on Cancer Cells with the CD19 Monoclonal Antibody Tafasitamab Improves the Activation, Antitumor Efficacy, and Safety Profile of CART19 Cell Therapy
Sakemura, Reona Leo
Manriquez-Roman, Claudia
Horvei, Paulina
Cox, Michelle J.
Huynh, Truc
Girsch, James H.
Sirpilla, Olivia
Yun, Kun
Stewart, Carli M.
Can, Ismail
Ogbodo, Ekene J.
Adada, Mohamad M.
Fonkoua, Lionel A. Kankeu
Hefazi, Mehrdad
Ruff, Michael W.
Ilieva-Babinsky, Kristina
Augsberger, Christian
Patra-Kneuer, Maria
Heitmuller, Christina
Steidl, Stefan
Parikh, Sameer A.
Ding, Wei
Kay, Neil E.
Nowakowski, Grzegorz S.
Siegler, Elizabeth L.
Kenderian, Saad S.
BLOOD, 2022, 140 : 2362 - 2364
[4] The Impact of Prior Treatment with a CD19 Targeting Monoclonal Antibody on Subsequent Treatment with CD19 Targeting CART Cell Therapy in Preclinical Models
Sakemura, Reona
Horvei, Paulina
Manriquez-Roman, Claudia
Ogbodo, Ekene J.
Tapper, Erin E.
Siegler, Elizabeth L.
Stewart, Carli M.
Schick, Kendall J.
Can, Ismail
Adada, Mohamad M.
Bezerra, Evandro D.
Fonkoua, Lionel A. Kankeu
Hefazi, Mehrdad
Ruff, Michael W.
Augsberger, Christian
Schanzer, Juergen
Patra-Kneuer, Maria
Heitmueller, Christina
Steidl, Stefan
Endell, Jan
Ding, Wei
Parikh, Sameer A.
Slager, Susan L.
Kay, Neil E.
Nowakowski, Grzegorz S.
Cox, Michelle J.
Kenderian, Saad S.
BLOOD, 2021, 138
[5] Results of ARI-0001 CART19 cell therapy in patients with relapsed/refractory CD19-positive acute lymphoblastic leukemia with isolated extramedullary disease
Ortiz-Maldonado, Valentin
Alonso-Saladrigues, Anna
Espanol-Rego, Marta
Martinez-Cibrian, Nuria
Faura, Anna
Magnano, Laura
Catala, Albert
Benitez-Ribas, Daniel
Gine, Eva
Diaz-Beya, Marina
Gonzalo Correa, Juan
Rovira, Montserrat
Montoro-Lorite, Mercedes
Martinez-Roca, Alexandra
Gerardo Rodriguez-Lobato, Luis
Cabezon, Raquel
Cid, Joan
Lozano, Miquel
Garcia-Rey, Enric
Conde, Nuria
Pedrals, Georgina
Rozman, Maria
Torrebadell, Montserrat
Setoain, Xavier
Rodriguez, Sonia
Esteve, Jordi
Pascal, Mariona
Urbano-Ispizua, Alvaro
Juan, Manel
Delgado, Julio
Rives, Susana
AMERICAN JOURNAL OF HEMATOLOGY, 2022, 97 (06) : 731 - 739
[6] CAR T-Cell Therapy Predictive Response Markers in Diffuse Large B-Cell Lymphoma and Therapeutic Options After CART19 Failure
Caballero, Ana Carolina
Escriba-Garcia, Laura
Alvarez-Fernandez, Carmen
Briones, Javier
FRONTIERS IN IMMUNOLOGY, 2022, 13
[7] Inpatient and Intensive Care Unit Resource Utilization after CD19-Targeted Chimeric Antigen Receptor T-Cell Therapy (CART19) for Pediatric Acute Lymphoblastic Leukemia (ALL)
Myers, Regina M.
Fitzgerald, Julie C.
DiNofia, Amanda
Wray, Lisa
Leahy, Allison Barz
Li, Yimei
Smith, Laura T.
Burrows, Evanette K.
Ramos, Mark
Motley, Laura S.
Khan, Raabia
Aplenc, Richard
Grupp, Stephan A.
Maude, Shannon L.
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2020, 26 (03) : S202 - S203
[8] Increased Cortical Glycolysis Following CD19 CART Therapy: A Radiographic Surrogate for an Altered Blood-Brain Barrier
Bukhari, Ali
Kesari, Vivek
Sirous, Reza
Holtzman, Noa G.
Lee, Seung Tae
Gahres, Natalie
Hutnick, Elizabeth
Ruehle, Kathleen
Kocoglu, Mehmet Hakan
Badros, Ashraf Z.
Yared, Jean A.
Hardy, Nancy M.
Rapoport, Aaron P.
Saboury, Babak
Dahiya, Saurabh
BLOOD, 2019, 134
[9] Preclinical optimization of a low cost PiggyBac transposase (PB) generated CD19-specific chimeric antigen receptor T cell (CART19) product for a first in man trial using local hospital cell manufacture
Bishop, David
Xu, Ning
Shen, Sylvie
O'Brien, Tracey
Gottlieb, David
Dolnikov, Alla
Micklethwaite, Kenneth
CANCER RESEARCH, 2017, 77
[10] INFECTIOUS COMPLICATIONS IN ARI-0001 CELL THERAPY (A3B1:CD8:4-1BB:CD3Z CART19) IN ADULT AND PEDIATRIC PATIENTS WITH RELAPSED/REFRACTORY MALIGNANT HEMOPATHIES CD19+
Ortiz-Maldonado, V
Alonso-Saladrigues, A.
Martinez-Roca, A.
Cardozo, C.
Baumann, T.
Diaz-Beya, M.
Torrebadell, M.
Catala, A.
Castro, P.
Fernandez, S.
Jordan, I
Esteve, J.
Yague, J.
Rovira, M.
Urbano-Izpizua, A.
Manel, J.
Noguera-Julian, A.
Puerta-Alcalde, P.
Garcia-Vidal, C.
Rives, S.
Delgado, J.
HAEMATOLOGICA, 2019, 104 : 315 - 315

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