Hedgehog signalling in allograft vasculopathy: a new therapeutic target?

被引：0
|
作者：
Rowell, Jasmine [1 ]
Lau, Ching-In [1 ]
Yanez, Diana C. [1 ]
Zhang, Eden [1 ]
Crompton, Tessa [1 ]
机构：
[1] UCL Great Ormond St Inst Child Hlth, London, England
来源：
TRENDS IN PHARMACOLOGICAL SCIENCES | 2023年 / 44卷 / 09期
基金：
英国生物技术与生命科学研究理事会;
关键词：
D O I：
10.1016/j.tips.2023.05.005
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Allograft vasculopathy (AV) leads to chronic rejection of organ transplants, but its causes are obscure. New research from the Jane-Wit lab-oratory showed that Sonic Hedge-hog (SHH) signalling from damaged graft endothelium drives vasculopathy by promoting proinflammatory cytokine production and NLRP3-inflammasome activation in alloreactive CD4(+)PTCH1(hi)PD-1(hi)T memory cells, offering new diagnostic and therapeutic strategies.
引用
收藏
页码：558 / 560
页数：3
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