New Biocides Based on N4-Alkylcytidines: Effects on Microorganisms and Application for the Protection of Cultural Heritage Objects of Painting

被引：2

作者：

Alexandrova, Liudmila A. ^{[1
]}

Oskolsky, Ivan A. ^{[1
]}

Makarov, Dmitry A. ^{[1
]}

Jasko, Maxim V. ^{[1
]}

Karpenko, Inna L. ^{[1
]}

Efremenkova, Olga V. ^{[2
]}

Vasilyeva, Byazilya F. ^{[2
]}

Avdanina, Darya A. ^{[3
]}

Ermolyuk, Anna A. ^{[3
]}

Benko, Elizaveta E. ^{[3
]}

Kalinin, Stanislav G. ^{[3
]}

Kolganova, Tat'yana V. ^{[3
]}

Berzina, Maria Ya. ^{[4
]}

Konstantinova, Irina D. ^{[4
]}

Chizhov, Alexander O. ^{[5
]}

Kochetkov, Sergey N. ^{[1
]}

Zhgun, Alexander A. ^{[3
]}

机构：

[1] Engelhardt Inst Mol Biol RAS, 32 Vavilov Str, Moscow 119991, Russia

[2] Gause Inst New Antibiot, 11 Bolshaya Pirogovskaya, Moscow 119021, Russia

[3] Res Ctr Biotechnol RAS, 33 Leninsky Ave, Moscow 119071, Russia

[4] Shemyakin Ovchinnikov Inst Bioorgan Chem RAS, 16-10 Miklukho Maklaya Str, Moscow 117997, Russia

[5] Zelinsky Inst Organ Chem RAS, 47 Leninsky Ave, Moscow 119991, Russia

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2024年 / 25卷 / 05期

基金：

俄罗斯科学基金会;

关键词：

nucleosides; N-4-alkylcytidines; antifungal activity; antibacterial activity; biocides; biodeterioration; protection of cultural heritage; ASPERGILLUS-TERREUS; DERIVATIVES; ANTIBIOTICS; NUCLEOSIDE; ANALOGS; SYN; 6-METHYLURIDINE; INHIBITORS; GENES;

D O I：

10.3390/ijms25053053

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The rapid increase in the antibiotic resistance of microorganisms, capable of causing diseases in humans as destroying cultural heritage sites, is a great challenge for modern science. In this regard, it is necessary to develop fundamentally novel and highly active compounds. In this study, a series of N-4-alkylcytidines, including 5- and 6-methylcytidine derivatives, with extended alkyl substituents, were obtained in order to develop a new generation of antibacterial and antifungal biocides based on nucleoside derivatives. It has been shown that N-4-alkyl 5- or 6-methylcytidines effectively inhibit the growth of molds, isolated from the paintings in the halls of the Ancient Russian Paintings of the State Tretyakov Gallery, Russia, Moscow. The novel compounds showed activity similar to antiseptics commonly used to protect works of art, such as benzalkonium chloride, to which a number of microorganisms have acquired resistance. It was also shown that the activity of N-4-alkylcytidines is comparable to that of some antibiotics used in medicine to fight Gram-positive bacteria, including resistant strains of Staphylococcus aureus and Mycobacterium smegmatis. N-4-dodecyl-5- and 6-methylcytidines turned out to be the best. This compound seems promising for expanding the palette of antiseptics used in painting, since quite often the destruction of painting materials is caused by joint fungi and bacteria infection.

引用

页数：20