Polygenic risk scores for dyslipidemia and atherosclerotic cardiovascular disease: Progress toward clinical implementation

被引：1

作者：

Levin, Michael G. ^{[1
]}

Rader, Daniel J. ^{[2
,3
]}

机构：

[1] Univ Penn, Perelman Sch Med, Dept Med, Div Cardiovasc Med, Philadelphia, PA USA

[2] Univ Penn, Perelman Sch Med, Dept Med, Div Translat Med & Therapeut, Philadelphia, PA 19104 USA

[3] Univ Penn, Perelman Sch Med, Dept Genet, Philadelphia, PA USA

来源：

BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM | 2023年 / 37卷 / 03期

关键词：

polygenic risk score; atherosclerosis; dyslipidemia; coronary artery disease; genetics; CORONARY-HEART-DISEASE; GENOME-WIDE ASSOCIATION; GENETIC RISK; PREDICTIVE ACCURACY; COMMON VARIANTS; LOCI; CHOLESTEROL; POLYMORPHISMS; METAANALYSIS; BIOMARKERS;

D O I：

10.1016/j.beem.2022.101702

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Recent discoveries from the past 15 years of human genetic association studies have provided new insights into the common genetic basis of coronary artery disease and its risk factors including molecular traits like circulating lipid/lipoprotein levels. Polygenic risk scores, which aggregate findings from these large genetic studies, have been developed to predict clinical disease and stratify treatment response in clinical trials. In this review, we describe common methods for calculating polygenic risk scores, highlight examples related to coronary artery disease and lipid traits, and discuss opportunities and challenges for clinical implementation. (c) 2022 Published by Elsevier Ltd.

引用

页数：13

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